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Article

Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome

  • Authors:
    • Jing Xiao
    • Jing Xiong
    • Fufan Zhu
    • Liang He
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 287-291
    |
    Published online on: October 10, 2012
       https://doi.org/10.3892/etm.2012.743
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Abstract

The aim of this study was to evaluate the effect of traditional treatment (prednisone and aspirin) and comprehensive treatment [prednisone, aspirin, low molecular weight heparin (LMWH) and IVIg] on the pregnancy outcome, obstetric complications and fetal outcome in women with antiphospholipid syndrome (APS). In the present trial, we observed and evaluated 129 women with APS. Eighty-seven patients received traditional treatment and 42 patients received comprehensive treatment. In the traditional treatment group and comprehensive treatment group, the live birth rate was 83.91 and 97.62% (P<0.05), respectively, and the obstetric morbidity was 22.99 and 7.14% (P<0.05), respectively. The neonatal weight in the comprehensive treatment group was increased compared with the traditional treatment group (P<0.05), however, no differences were found in gestational age at delivery or preterm labor. Comprehensive treatment improved the result of gestation and reduced obstetric complications, and is a more effective treatment for APS than the traditional method using prednisone and aspirin.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao J, Xiong J, Zhu F and He L: Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Exp Ther Med 5: 287-291, 2013.
APA
Xiao, J., Xiong, J., Zhu, F., & He, L. (2013). Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Experimental and Therapeutic Medicine, 5, 287-291. https://doi.org/10.3892/etm.2012.743
MLA
Xiao, J., Xiong, J., Zhu, F., He, L."Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome". Experimental and Therapeutic Medicine 5.1 (2013): 287-291.
Chicago
Xiao, J., Xiong, J., Zhu, F., He, L."Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome". Experimental and Therapeutic Medicine 5, no. 1 (2013): 287-291. https://doi.org/10.3892/etm.2012.743
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao J, Xiong J, Zhu F and He L: Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Exp Ther Med 5: 287-291, 2013.
APA
Xiao, J., Xiong, J., Zhu, F., & He, L. (2013). Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Experimental and Therapeutic Medicine, 5, 287-291. https://doi.org/10.3892/etm.2012.743
MLA
Xiao, J., Xiong, J., Zhu, F., He, L."Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome". Experimental and Therapeutic Medicine 5.1 (2013): 287-291.
Chicago
Xiao, J., Xiong, J., Zhu, F., He, L."Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome". Experimental and Therapeutic Medicine 5, no. 1 (2013): 287-291. https://doi.org/10.3892/etm.2012.743
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