Anti-inflammatory activity of Yanshu spraying agent in animal models

Zhang,Jianqiao; Wang,Hongsheng; Wang,Tian; Chong,Yating; Yu,Pengfei; Lu,Chengwen; Xue,Yunli; Fu,Fenghua; Zhang,Leiming

doi:10.3892/etm.2012.761

January 2013 Volume 5 Issue 1

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January 2013 Volume 5 Issue 1

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Article

Anti-inflammatory activity of Yanshu spraying agent in animal models

Authors:
- Jianqiao Zhang
- Hongsheng Wang
- Tian Wang
- Yating Chong
- Pengfei Yu
- Chengwen Lu
- Yunli Xue
- Fenghua Fu
- Leiming Zhang
View Affiliations / Copyright

Affiliations: Department of Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong 264005, P.R. China, Nanjing Luye Sike Pharmaceutical Co., Ltd, Nanjing, Jiangsu 210061, P.R. China
Pages: 73-76
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Published online on: October 25, 2012

https://doi.org/10.3892/etm.2012.761
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Abstract

Acute pharyngitis is characterized by an inflammation of the mucous membranes in the pharynx. Yanshu spraying agent was prepared according to the traditional Chinese formulation for the treatment of acute pharyngitis. The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan‑induced paw edema in rats by measuring the degree of edema in the animal models. The histopathology and the levels of prostaglandin E2 (PGE2) and cycloxygenase-2 (COX-2) in the hind paws of the carrageenan-treated rats were also analyzed. The results showed that Yanshu significantly reduced ear edema in the mice and paw edema in the rats. Furthermore, treatment with Yanshu also reduced the number of inflammatory cells in tissue and decreased the production of PGE2 and COX-2. These results suggest that Yanshu possesses potent anti‑inflammatory activity mediated by the inhibition of COX-2 expression which, in turn, downregulates the inflammatory mediator PGE2.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anti-inflammatory activity of Yanshu spraying agent in animal models

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