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Article

Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation

  • Authors:
    • Yun Wang
    • Zhong‑Ze Zhang
    • Yun Wu
    • Jia Zhan
    • Xiang‑Hu He
    • Yan‑Lin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 315-319
    |
    Published online on: October 25, 2012
       https://doi.org/10.3892/etm.2012.766
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Abstract

Honokiol, a potent radical scavenger, has been demonstrated to ameliorate cerebral infarction following ischemia/reperfusion (I/R) injury. However, its effects on myocardial I/R injury remain unclear. The present study aimed to examine the effects of honokiol on myocardial I/R injury and to investigate its potential cardioprotective mechanisms. Sprague‑Dawley rats were pretreated with honokiol and exposed to a 30­‑min myocardial ischemia followed by 2‑h coronary reperfusion. Myocardial I/R-induced infarct size and biochemical and histological changes were compared. The expression of nuclear factor κB(NF‑κB; p65) was assessed by western blotting. Pretreatment with honokiol significantly reduced infarct size, and serum creatine kinase (CK) and lactate dehydrogenase (LDH) release compared with those in the I/R group following a 2‑h reperfusion. The malondialdehyde (MDA) level, myeloperoxidase (MPO) activity, concentrations of tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 and expression level of NF‑κB were all reduced by honokiol pretreatment, while honokiol inhibited the decreases in superoxide dismutase (SOD) and catalase (CAT) activities. In addition, less neutrophil infiltration and histopathological damage in the myocardium were observed in the honokiol‑pretreated group. These findings indicate that honokiol pretreatment diminished myocardial I/R injury through attenuation of oxidative stress and inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhang ZZ, Wu Y, Zhan J, He XH and Wang YL: Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation. Exp Ther Med 5: 315-319, 2013.
APA
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., & Wang, Y. (2013). Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation. Experimental and Therapeutic Medicine, 5, 315-319. https://doi.org/10.3892/etm.2012.766
MLA
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., Wang, Y."Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation". Experimental and Therapeutic Medicine 5.1 (2013): 315-319.
Chicago
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., Wang, Y."Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation". Experimental and Therapeutic Medicine 5, no. 1 (2013): 315-319. https://doi.org/10.3892/etm.2012.766
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhang ZZ, Wu Y, Zhan J, He XH and Wang YL: Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation. Exp Ther Med 5: 315-319, 2013.
APA
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., & Wang, Y. (2013). Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation. Experimental and Therapeutic Medicine, 5, 315-319. https://doi.org/10.3892/etm.2012.766
MLA
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., Wang, Y."Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation". Experimental and Therapeutic Medicine 5.1 (2013): 315-319.
Chicago
Wang, Y., Zhang, Z., Wu, Y., Zhan, J., He, X., Wang, Y."Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation". Experimental and Therapeutic Medicine 5, no. 1 (2013): 315-319. https://doi.org/10.3892/etm.2012.766
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