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Article

Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis

  • Authors:
    • Min Zhang
    • Feng‑Lan Wang
    • Jian‑Yun Zhu
    • Yu‑Bao Zheng
    • Qi‑Yi Zhao
    • Yu‑Rong Gu
    • Qi Zhang
    • Yu‑Tian Chong
    • Zhi‑Liang Gao
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, P.R. China, Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, P.R. China
  • Pages: 143-149
    |
    Published online on: October 25, 2012
       https://doi.org/10.3892/etm.2012.767
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Abstract

The ability of lymphocytes and macrophage‑derived cytokines and chemokines to modulate the activation of stromal cells during immune responses is well‑documented, but few studies have investigated whether liver myofibroblasts shape the phenotype and function of monocytes in liver disease. In the present study, Kupffer cells were demonstrated to be activated in the inflamed livers of patients with cirrhosis and be in close contact with liver myofibroblasts. The Kupffer cells from cirrhotic livers expressed significantly elevated levels of PD‑L1 (also termed B7‑H1), TLR4, CD80, CD32 and CD64 relative to those from normal livers. Consistent with this finding, the expression of these surface molecules was significantly upregulated in monocytes following exposure to liver myofibroblasts originating from inflamed livers. Accordingly, the liver myofibroblast‑exposed monocytes exhibited a significant increase in dextran endocytosis. These data reveal that bidirectional interactions between liver myofibroblasts and Kupffer cells may function as an ‘amplification loop’ to enhance inflammation further in the liver. Liver myofibroblasts are central in the pathogenesis of liver diseases and should be considered as targets for the rational design of effective immune‑based anti‑inflammation therapies. Furthermore, it was also demonstrated that skin fibroblasts were as effective as liver myofibroblasts at inducing monocyte activation, suggesting that fibroblasts, which are numerous in the body, may represent an underrated cell population that is actively involved in immunomodulatory functions.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Wang FL, Zhu JY, Zheng YB, Zhao QY, Gu YR, Zhang Q, Chong YT and Gao ZL: Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Exp Ther Med 5: 143-149, 2013.
APA
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y. ... Gao, Z. (2013). Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Experimental and Therapeutic Medicine, 5, 143-149. https://doi.org/10.3892/etm.2012.767
MLA
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y., Zhang, Q., Chong, Y., Gao, Z."Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis". Experimental and Therapeutic Medicine 5.1 (2013): 143-149.
Chicago
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y., Zhang, Q., Chong, Y., Gao, Z."Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis". Experimental and Therapeutic Medicine 5, no. 1 (2013): 143-149. https://doi.org/10.3892/etm.2012.767
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Wang FL, Zhu JY, Zheng YB, Zhao QY, Gu YR, Zhang Q, Chong YT and Gao ZL: Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Exp Ther Med 5: 143-149, 2013.
APA
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y. ... Gao, Z. (2013). Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Experimental and Therapeutic Medicine, 5, 143-149. https://doi.org/10.3892/etm.2012.767
MLA
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y., Zhang, Q., Chong, Y., Gao, Z."Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis". Experimental and Therapeutic Medicine 5.1 (2013): 143-149.
Chicago
Zhang, M., Wang, F., Zhu, J., Zheng, Y., Zhao, Q., Gu, Y., Zhang, Q., Chong, Y., Gao, Z."Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis". Experimental and Therapeutic Medicine 5, no. 1 (2013): 143-149. https://doi.org/10.3892/etm.2012.767
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