The prognostic value of copeptin for acute intracerebral hemorrhage patients

Zhang,Aimei; Li,Jun; Li,Xiaoyun; Song,Li; Li,Hongfang

doi:10.3892/etm.2012.804

February 2013 Volume 5 Issue 2

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February 2013 Volume 5 Issue 2

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Article

The prognostic value of copeptin for acute intracerebral hemorrhage patients

Authors:
- Aimei Zhang
- Jun Li
- Xiaoyun Li
- Li Song
- Hongfang Li
View Affiliations / Copyright

Affiliations: Department of Neurology, Affiliated Hospital of Ji Ning Medical University, Jining 272029, P.R. China, Graduate School of Tianjin Medical University, Tianjin 300070, P.R. China
Pages: 467-470
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Published online on: November 7, 2012

https://doi.org/10.3892/etm.2012.804
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Abstract

The aim of the current study was to examine the prognostic value of copeptin for acute intracerebral hemorrhage (ICH) patients. A total of 120 patients were recruited. The plasma copeptin levels were measured using sandwich immunoassays. The hematoma volume, Glasgow coma scale (GCS) and ICH score were evaluated. The 90-day functional outcomes were measured with the modified Rankin scale (mRS). Copeptin correlated positively with hematoma volume (r=0.61, P=0.000), Hemphill scores (r=0.78, P=0.000) and white blood cell counts (r=0.58, P=0.000), whereas copeptin correlated negatively with GCS scores (r=-0.79, P=0.000). Copeptin levels were also higher in patients with an unfavorable functional outcome at 90 days than in patients with a favorable outcome (4.14±0.87 vs. 3.09±0.30 ng/ml; t=8.001, P=0.00). Monovariate logistic regression analysis results suggest that copeptin is a predictor of the 90-day functional outcomes of ICH patients (OR=3.17, 95% CI 2.01-4.35, P=0.003. Multivariate logistic regression analysis results indicate that copeptin is an independent predictor of the 90-day functional outcomes of ICH patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The prognostic value of copeptin for acute intracerebral hemorrhage patients

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