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Article

Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients

  • Authors:
    • Jingjun Chen
    • Junqiang Yan
    • Xueping Han
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Neurology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 489-494
    |
    Published online on: November 13, 2012
       https://doi.org/10.3892/etm.2012.811
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Abstract

Laparoscopic cholecystectomy is performed with increasing frequency in aging populations. However, in elderly patients, cognitive dysfunction following surgery may impair the outcome of surgical procedures. Dexmedetomidine (DEX) has been demonstrated to have a neuroprotectve effect in animal experiments. However, it is unclear whether DEX also has a neuroprotective effect in human patients. The present study was a randomized, placebo-controlled double-blind trial of 126 patients who had undergone laparoscopic cholecystectomy, using clinical interviews to determine whether intravenously administrated DEX during general anesthesia ameliorates cognitive function impairment. The cognitive deficit of each patient was assessed using the Mini‑Mental State Examination (MMSE). The scores on the MMSE for the DEX and control groups one week after surgery (DEX group, 27.6±1.2; control group, 25.7±1.5) were significantly different (P=0.005). The MMSE scores of patients ≤65 years old were significantly higher than those of patients >65 one week after surgery. The MMSE scores were significantly different between the two age groups in the control patients (≤65 years old, 28.3±1.2; >65 years old, 26.6±2.1; P=0.036), while the difference was not statistically significant in the DEX-treated patients. Eight patients in the DEX group and 15 patients in the control group had mild cognitive impairment (26≥ MMSE score ≥21) although the difference was not statistically significant. The findings of the present study support the hypothesis that DEX administration may be an effective method for ameliorating postoperative cognitive impairment in elderly patients who have undergone laparoscopic cholecystectomy. Further research is required to confirm the findings of the present study.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Yan J and Han X: Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Exp Ther Med 5: 489-494, 2013.
APA
Chen, J., Yan, J., & Han, X. (2013). Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Experimental and Therapeutic Medicine, 5, 489-494. https://doi.org/10.3892/etm.2012.811
MLA
Chen, J., Yan, J., Han, X."Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients". Experimental and Therapeutic Medicine 5.2 (2013): 489-494.
Chicago
Chen, J., Yan, J., Han, X."Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients". Experimental and Therapeutic Medicine 5, no. 2 (2013): 489-494. https://doi.org/10.3892/etm.2012.811
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Yan J and Han X: Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Exp Ther Med 5: 489-494, 2013.
APA
Chen, J., Yan, J., & Han, X. (2013). Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Experimental and Therapeutic Medicine, 5, 489-494. https://doi.org/10.3892/etm.2012.811
MLA
Chen, J., Yan, J., Han, X."Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients". Experimental and Therapeutic Medicine 5.2 (2013): 489-494.
Chicago
Chen, J., Yan, J., Han, X."Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients". Experimental and Therapeutic Medicine 5, no. 2 (2013): 489-494. https://doi.org/10.3892/etm.2012.811
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