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Article

Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis

  • Authors:
    • Jie Wang
    • Gang Wu
    • Baojin Ma
    • Jianhua Wu
    • Duan Cai
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Huashan Hospital, Fudan University, Shanghai, P.R. China
  • Pages: 461-466
    |
    Published online on: November 19, 2012
       https://doi.org/10.3892/etm.2012.817
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Abstract

The aim of the current study was to investigate the therapeutic effect of Tripterygium wilfordii Hook F multiglycosides (TWG) on gut barrier dysfunction in rats with acute necrotizing pancreatitis (ANP). ANP was induced in rats using 3.5% sodium taurocholate. The rats were divided into 3 groups: the sham operation (SO), ANP and ANP+TWG groups. Biochemical and pathological change of pancreatic tissue and ileal mucosa, bacterial cultures and the survival rate were measured following surgery and treatment. TWG treatment significantly decreased amylase and lipase activities and plasma endotoxin and D-lactate levels. Edema and inflammation in the pancreas and ileal mucosa were alleviated. Positive bacterial cultures were significantly reduced. The survival rate of the rats in the ANP+TWG group was higher than that of the rats in the ANP group. TWG treatment showed beneficial effects by protecting the pancreas from bacterial infection caused by gut barrier dysfunction and improving the outcomes of the rats with ANP.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wu G, Ma B, Wu J and Cai D: Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis. Exp Ther Med 5: 461-466, 2013.
APA
Wang, J., Wu, G., Ma, B., Wu, J., & Cai, D. (2013). Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis. Experimental and Therapeutic Medicine, 5, 461-466. https://doi.org/10.3892/etm.2012.817
MLA
Wang, J., Wu, G., Ma, B., Wu, J., Cai, D."Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis". Experimental and Therapeutic Medicine 5.2 (2013): 461-466.
Chicago
Wang, J., Wu, G., Ma, B., Wu, J., Cai, D."Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis". Experimental and Therapeutic Medicine 5, no. 2 (2013): 461-466. https://doi.org/10.3892/etm.2012.817
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wu G, Ma B, Wu J and Cai D: Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis. Exp Ther Med 5: 461-466, 2013.
APA
Wang, J., Wu, G., Ma, B., Wu, J., & Cai, D. (2013). Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis. Experimental and Therapeutic Medicine, 5, 461-466. https://doi.org/10.3892/etm.2012.817
MLA
Wang, J., Wu, G., Ma, B., Wu, J., Cai, D."Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis". Experimental and Therapeutic Medicine 5.2 (2013): 461-466.
Chicago
Wang, J., Wu, G., Ma, B., Wu, J., Cai, D."Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis". Experimental and Therapeutic Medicine 5, no. 2 (2013): 461-466. https://doi.org/10.3892/etm.2012.817
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