Effect of αlipoic acid and silymarin on bladder outlet obstruction

  • Authors:
    • Abidin Yıldırım
    • Barbaros Başeskioğlu
    • Halide E. Temel
    • Nilüfer Erkasap
    • Aydın Yenilmez
    • Sema Uslu
    • Caner Özer
    • Mete Ozkurt
    • Turgut Dönmez
  • View Affiliations

  • Published online on: November 23, 2012     https://doi.org/10.3892/etm.2012.831
  • Pages: 596-602
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Abstract

The aim of the present study was to determine whether the treatment of obstructed rat bladders with αlipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction (BOO). A total of 32 adult Sprague Dawley rats were divided into four groups (n=8 per group): sham (placebo surgery) animals with no treatment (group 1); control animals with surgically induced BOO (group 2); obstructed rats treated with ALA (group 3); and obstructed rats treated with silymarin (group 4). Histological evaluation, bladder weights, collagen structure, TdT‑mediated biotin nick end‑labeling (TUNEL), inducible nitric oxide sentase (iNOS) mRNA levels, malondialdehyde (MDA) levels and tumor necrosis factor (TNF) levels were investigated. The ALA-treated group had similar bladder weights, collagen levels and TUNEL positivity and decreased iNOS levels compared with the control group, while the silymarin group exhibited further differences. Serum MDA and TNF‑α levels were both decreased in the ALA and silymarin groups. ALA treatment reduced the increased oxidative stress and bladder inflammation caused by BOO and may contribute to the protection of bladder function.
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February 2013
Volume 5 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
APA
Yıldırım, A., Başeskioğlu, B., Temel, H.E., Erkasap, N., Yenilmez, A., Uslu, S. ... Dönmez, T. (2013). Effect of αlipoic acid and silymarin on bladder outlet obstruction. Experimental and Therapeutic Medicine, 5, 596-602. https://doi.org/10.3892/etm.2012.831
MLA
Yıldırım, A., Başeskioğlu, B., Temel, H. E., Erkasap, N., Yenilmez, A., Uslu, S., Özer, C., Ozkurt, M., Dönmez, T."Effect of αlipoic acid and silymarin on bladder outlet obstruction". Experimental and Therapeutic Medicine 5.2 (2013): 596-602.
Chicago
Yıldırım, A., Başeskioğlu, B., Temel, H. E., Erkasap, N., Yenilmez, A., Uslu, S., Özer, C., Ozkurt, M., Dönmez, T."Effect of αlipoic acid and silymarin on bladder outlet obstruction". Experimental and Therapeutic Medicine 5, no. 2 (2013): 596-602. https://doi.org/10.3892/etm.2012.831