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Article

Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats

  • Authors:
    • Xin Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, P.R. China
  • Pages: 555-560
    |
    Published online on: November 28, 2012
       https://doi.org/10.3892/etm.2012.840
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Abstract

Hawk tea (Litsea coreana Levl. var. lanuginose) is a traditional Chinese drink similar to green tea. In the present study, the preventive effects of Hawk tea on hepatic damage induced by carbon tetrachloride (CCl4) were studied in Sprague‑Dawley rats. Silymarin was used as a positive control. Hawk tea was successfully shown to prevent hepatic damage in the rats. Serum levels of AST, ALT and LDH were significantly decreased when the rats were treated with varying concentrations of Hawk tea compared with silymarin (P<0.05). The lowest enzyme activities were exhibited in the 400 mg/kg Hawk tea group. This group showed reduced levels of the serum proinflammatory cytokines IL‑6, IFN‑γ and TNF‑α. In particular, the IFN‑γ level decreased markedly compared with the other concentration groups. The histopathology sections of liver tissue in the 400 mg/kg Hawk tea group recovered well from the CCl4 damage, but the sections of the other concentration groups showed necrosis to a more serious degree. Reverse transcription‑polymerase chain reaction (RT‑PCR) and western blot analyses of the inflammation‑related genes iNOS, COX‑2, TNF‑α and IL‑1β in the rat livers were tested. The 400 mg/kg Hawk tea group showed significantly decreased mRNA and protein expression levels of iNOS, COX‑2, TNF‑α and IL‑1β compared with the control group. Accordingly, 400 mg/kg Hawk tea potentially contributes to the prevention of CCl4‑induced hepatic damage in vivo. A 200 or 100 mg/kg dose of Hawk tea also demonstrated preventive effects against hepatic damage.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X: Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats. Exp Ther Med 5: 555-560, 2013.
APA
Zhao, X. (2013). Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats. Experimental and Therapeutic Medicine, 5, 555-560. https://doi.org/10.3892/etm.2012.840
MLA
Zhao, X."Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats". Experimental and Therapeutic Medicine 5.2 (2013): 555-560.
Chicago
Zhao, X."Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats". Experimental and Therapeutic Medicine 5, no. 2 (2013): 555-560. https://doi.org/10.3892/etm.2012.840
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X: Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats. Exp Ther Med 5: 555-560, 2013.
APA
Zhao, X. (2013). Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats. Experimental and Therapeutic Medicine, 5, 555-560. https://doi.org/10.3892/etm.2012.840
MLA
Zhao, X."Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats". Experimental and Therapeutic Medicine 5.2 (2013): 555-560.
Chicago
Zhao, X."Hawk tea (Litsea coreana Levl. var. lanuginose) attenuates CCl4‑induced hepatic damage in Sprague‑Dawley rats". Experimental and Therapeutic Medicine 5, no. 2 (2013): 555-560. https://doi.org/10.3892/etm.2012.840
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