The value of T2*-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families

Liu,Xue-Wu; Wang,Shu-Hua; Chi,Zhao-Fu; Su,Li-Jun; Zhao,Xiu-He; Wang,Sheng-Jun

doi:10.3892/etm.2012.845

February 2013 Volume 5 Issue 2

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February 2013 Volume 5 Issue 2

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Article

The value of T2*-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families

Authors:
- Xue-Wu Liu
- Shu-Hua Wang
- Zhao-Fu Chi
- Li-Jun Su
- Xiu-He Zhao
- Sheng-Jun Wang
View Affiliations / Copyright

Affiliations: Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
Pages: 448-452
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Published online on: November 30, 2012

https://doi.org/10.3892/etm.2012.845
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Abstract

The aim of this study was to investigate the value of T2*-weighted gradient echo imaging (GRE T2*-WI) for the detection of familial cerebral cavernous malformation (FCCM). Twenty-six members of 2 families with FCCM were examined using computed tomography (CT), conventional magnetic resonance imaging (MRI) and GRE T2*-WI sequences. We identified 12 cases of FCCM using GRE T2*-WI sequences. These 12 patients had multiple lesions (mean 23). The lesions were most commonly located in the ganglia. Other areas included the cortex-subcortex, thalamus, cerebellum and brainstem. These lesions appeared as a reticulated core of mixed signal intensity with a surrounding rim of decreased signal intensity representing hemosiderin from previous hemorrhages. The mean numbers of lesions and cases of FCCM identified by various conventional MRI sequences were 5-17 and 3-9, respectively. Conventional MRI examination involved T1‑weighted imaging (T1WI), T2-weighted imaging (T2WI), T2‑fluid‑attenuated inversion recovery (T2Flair), diffusion‑weighted imaging (DWI) and spin-echo imaging (SE) sequences, in that order. The numbers of lesions identified by MRI were fewer than those identified by GRE T2*-WI. CT only identified 3 cases with large lesions combined with hemorrhage and calcification. These findings suggest that GRE T2*-WI is the first choice when diagnosing FCCM compared with CT and conventional MRI.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The value of T2*-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families

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