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Article

Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort

  • Authors:
    • D. Mparmpakas
    • A. Goumenou
    • E. Zachariades
    • G. Pados
    • Y. Gidron
    • E. Karteris
  • View Affiliations / Copyright

    Affiliations: Centre for Cell and Chromosome Biology, Division of Biosciences, Brunel University, Uxbridge, UK, Department of Obstetrics and Gynecology, University Hospital, University of Crete Medical School, Heraklion, Crete, Greece, University of Thessaloniki Medical School, Thessaloniki, Greece, Free University of Brussels (VUB), Brussels, Belgium
  • Pages: 411-418
    |
    Published online on: December 4, 2012
       https://doi.org/10.3892/etm.2012.849
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Abstract

Pregnancy is associated with major physiological and future psychosocial changes, and maternal adaptation to these changes is crucial for normal foetal development. Psychological stress in pregnancy predicts an earlier birth and lower birth weight. Pregnancy-specific stress contributes directly to preterm delivery. The importance of nutrition and exercise during pregnancy with regard to pregnancy outcome has long been acknowledged. This importance has only been further emphasized by the recent changes in food quality and availability, lifestyle changes and a new understanding of foetal programming's effects on adult outcomes. We hypothesised that for a successful pregnancy certain events at a nutritional, immune, psycho-emotional and genetic level should be tightly linked. Therefore, in this study we followed an ‘integrative’ approach to investigate how maternal stress, nutrition, pregnancy planning and exercise influence pregnancy outcome. A key finding of our study is that there was a significant reduction in the intake of alcohol, caffeine-containing and sugary drinks during pregnancy. However, passive smoking in the household remained unchanged. In terms of immune profile, a significant inverse correlation was noted between difficulty to ‘fight’ an infection and number of colds (r=-0.289, P=0.003) as well as the number of infections (r=-0.446, P<0.0001) during pregnancy. The vast majority of the pregnant women acquired a more sedentary lifestyle in the third trimester. In planned, but not in unplanned, pregnancies stress predicted infant weight, independent of age and body mass index (BMI). Notably, in mothers with negative attitudes towards the pregnancy, those with an unplanned pregnancy gave birth to infants with significantly higher weights than those with planned pregnancies. Collectively these data suggest that there is a higher order of complexity, possibly involving gene-environment interactions that work together to ensure a positive outcome for the mother as well as the foetus.
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1. 

Shapira N: Prenatal nutrition: a critical window of opportunity for mother and child. Womens Health (Lond Engl). 4:639–656. 2008. View Article : Google Scholar : PubMed/NCBI

2. 

Vujkovic M, Steegers EA, Looman CW, Ocké MC, van der Spek PJ and Steegers-Theunissen RP: The maternal Mediterranean dietary pattern is associated with a reduced risk of spina bifida in the offspring. BJOG. 116:408–415. 2009. View Article : Google Scholar : PubMed/NCBI

3. 

de Batlle J, Garcia-Aymerich J, Barraza-Villarreal A, Antó JM and Romieu I: Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy. 63:1310–1316. 2008.PubMed/NCBI

4. 

Mariscal-Arcas M, Rivas A, Monteagudo C, Granada A, Cerrillo I and Olea-Serrano F: Proposal of a Mediterranean diet index for pregnant women. Br J Nutr. 102:744–749. 2009. View Article : Google Scholar : PubMed/NCBI

5. 

Marcus SM and Heringhausen JE: Depression in childbearing women: when depression complicates pregnancy. Prim Care. 36:151–165. 2009. View Article : Google Scholar : PubMed/NCBI

6. 

Lobel M, Cannella DL, Graham JE, DeVincent C, Schneider J and Meyer BA: Pregnancy-specific stress, prenatal health behaviours, and birth outcomes. Health Psychol. 27:604–615. 2008. View Article : Google Scholar : PubMed/NCBI

7. 

Karaçam Z and Ançel G: Depression, anxiety and influencing factors in pregnancy: a study in a Turkish population. Midwifery. 25:344–356. 2009.PubMed/NCBI

8. 

Paffenbarger RS Jr, Wing AL and Hyde RT: Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 108:161–175. 1978.PubMed/NCBI

9. 

Wang L, Wang X, Wang W, Chen C, Ronnennberg AG, Guang W, Huang A, Fang Z, Zang T, Wang L and Xu X: Stress and dysmenorrhoea: a population based prospective study. Occup Environ Med. 61:1021–1026. 2004. View Article : Google Scholar : PubMed/NCBI

10. 

Mendelsohn C: Women who smoke - a review of the evidence. Aust Fam Physician. 40:403–407. 2010.

11. 

Hackshaw A, Rodeck C and Boniface S: Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls. Hum Reprod Update. 17:589–604. 2011. View Article : Google Scholar : PubMed/NCBI

12. 

Jones LL, Hashim A, McKeever T, Cook DG, Britton J and Leonardi-Bee J: Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis. Respir Res. 12:52011. View Article : Google Scholar : PubMed/NCBI

13. 

Goldenberg RL, McClure EM, Saleem S and Reddy UM: Infection-related stillbirths. Lancet. 375:1482–1490. 2010. View Article : Google Scholar : PubMed/NCBI

14. 

Goldenberg RL, Hauth JC and Andrews WW: Intrauterine infection and preterm delivery. N Engl J Med. 342:1500–1507. 2000. View Article : Google Scholar : PubMed/NCBI

15. 

Conde-Agudelo A, Villar J and Lindheimer M: Maternal infection and risk of preeclampsia: systematic review and meta-analysis. Am J Obstet Gynecol. 198:7–22. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Lain SJ, Roberts CL, Warning J, Vivian-Taylor J and Ford JB: A survey of acute self-reported infections in pregnancy. BMJ Open. 1:e0000832011.PubMed/NCBI

17. 

Kuczkowski KM: Caffeine in pregnancy. Arch Gynecol Obstet. 280:695–698. 2009. View Article : Google Scholar

18. 

Wen W, Shu XO, Jacobs DR Jr and Brown JE: The associations of maternal caffeine consumption and nausea with spontaneous abortion. Epidemiology. 12:38–42. 2001. View Article : Google Scholar : PubMed/NCBI

19. 

Adeney KL, Williams MA, Schiff MA, Qiu C and Sorensen TK: Coffee consumption and the risk of gestational diabetes mellitus. Acta Obstet Gynecol Scand. 86:161–166. 2007. View Article : Google Scholar : PubMed/NCBI

20. 

Crozier TW, Stalmach A, Lean ME and Crozier A: Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct. 3:30–33. 2012. View Article : Google Scholar : PubMed/NCBI

21. 

Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A and Feeley M: Effects of caffeine on human health. Food Addit Contam. 20:1–30. 2003. View Article : Google Scholar

22. 

Block G: Foods contributing to energy intake in the US: data from NHANES III and NHANES 1999–2000. J Food Compost Anal. 17:439–447. 2004.

23. 

Schulze MB, Liu S, Rimm EB, Manson JE, Willett WC and Hu FB: Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr. 80:348–356. 2004.PubMed/NCBI

24. 

Halldorsson TI, Strøm M, Petersen SB and Olsen SF: Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women. Am J Clin Nutr. 92:626–633. 2010. View Article : Google Scholar : PubMed/NCBI

25. 

Wen LM, Flood VM, Simpson JM, Rissel C and Baur LA: Dietary behaviours during pregnancy: findings from first-time mothers in southwest Sydney, Australia. Int J Behav Nutr Phys Act. 7:132010. View Article : Google Scholar : PubMed/NCBI

26. 

Baldini M, Pasqui F, Bordoni A and Maranesi M: Is the Mediterranean lifestyle still a reality? Evaluation of food consumption and energy expenditure in Italian and Spanish university students. Public Health Nutr. 12:148–155. 2009. View Article : Google Scholar : PubMed/NCBI

27. 

Melzer K, Schutz Y, Boulvain M and Kayser B: Physical activity and pregnancy: cardiovascular adaptations, recommendations and pregnancy outcomes. Sports Med. 40:493–507. 2010. View Article : Google Scholar : PubMed/NCBI

28. 

Coleman PK, Reardon DC and Cougle JR: Substance use among pregnant women in the context of previous reproductive loss and desire for current pregnancy. Br J Health Psychol. 10:255–268. 2005. View Article : Google Scholar : PubMed/NCBI

29. 

Robbins AS, Chao SY, Frost LZ and Fonseca VP: Unplanned pregnancy among active duty service women, US Air Force, 2001. Mil Med. 170:38–43. 2005.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mparmpakas D, Goumenou A, Zachariades E, Pados G, Gidron Y and Karteris E: Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort. Exp Ther Med 5: 411-418, 2013.
APA
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., & Karteris, E. (2013). Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort. Experimental and Therapeutic Medicine, 5, 411-418. https://doi.org/10.3892/etm.2012.849
MLA
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., Karteris, E."Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort". Experimental and Therapeutic Medicine 5.2 (2013): 411-418.
Chicago
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., Karteris, E."Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort". Experimental and Therapeutic Medicine 5, no. 2 (2013): 411-418. https://doi.org/10.3892/etm.2012.849
Copy and paste a formatted citation
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Spandidos Publications style
Mparmpakas D, Goumenou A, Zachariades E, Pados G, Gidron Y and Karteris E: Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort. Exp Ther Med 5: 411-418, 2013.
APA
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., & Karteris, E. (2013). Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort. Experimental and Therapeutic Medicine, 5, 411-418. https://doi.org/10.3892/etm.2012.849
MLA
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., Karteris, E."Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort". Experimental and Therapeutic Medicine 5.2 (2013): 411-418.
Chicago
Mparmpakas, D., Goumenou, A., Zachariades, E., Pados, G., Gidron, Y., Karteris, E."Immune system function, stress, exercise and nutrition profile can affect pregnancy outcome: Lessons from a Mediterranean cohort". Experimental and Therapeutic Medicine 5, no. 2 (2013): 411-418. https://doi.org/10.3892/etm.2012.849
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