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Article

Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB

  • Authors:
    • Kedan Chu
    • Haiyin Zheng
    • Huang Li
    • Yuqin Zhang
    • Xun Zhang
    • Wei Xu
    • Lidian Chen
  • View Affiliations / Copyright

    Affiliations: Pharmacy College, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China, Integrative Medicine College, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China, Faculty of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China
  • Pages: 423-428
    |
    Published online on: December 5, 2012
       https://doi.org/10.3892/etm.2012.853
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Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease and may lead to joint damage, synovial membrane destruction and cartilage and bone damage. RA is closely associated with increased expression of interleukin (IL)-6, IL-8, tumor necrosis factor-α (TNF-α) and nuclear transcription factor-κB (NF-κB). Therefore, inhibition of the expression of IL-6, IL-8, TNF-α and NF-κB is a promising strategy for the development of novel anti-RA therapies. The aim of this study was to investigate the effect of shuangtengbitong tincture (STBT) on the expression of IL-6, IL-8, TNF-α and NF-κB in synovial tissues of rats with collagen-induced arthritis (CIA). STBT as a clinical prescription created at Fujian University of Traditional Chinese Medicines (TCM) Affiliated People's Hospital has been shown to be clinically effective in the treatment of RA. The model of Wistar rats with CIA was created using bovine type II collagen. The two treatment groups with CIA were administered STBT (1 ml per time) or Votalin (~1 cm per time) for ~1 month continuously. Following treatment, STBT suppressed paw swelling significantly (P<0.05) compared with the model group. STBT also improved pathological changes, STBT-treated rats showed a significant improvement in synovial hyperplasia, inflammatory infiltration, cartilage and bone destruction and other symptoms. The protein expression levels of IL-6, IL-8, TNF-α and NF-κB were markedly suppressed in synovial tissues of STBT-treated and Votalin-treated rats. Our findings demonstrate for the first time that STBT markedly reduces paw swelling, improves pathological changes and increases the expression of IL-6, IL-8, TNF-α and NF-κB in synovial tissues of CIA rats, which may partially explain the anti-RA activity of STBT.
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Copy and paste a formatted citation
Spandidos Publications style
Chu K, Zheng H, Li H, Zhang Y, Zhang X, Xu W and Chen L: Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB. Exp Ther Med 5: 423-428, 2013.
APA
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., & Chen, L. (2013). Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB. Experimental and Therapeutic Medicine, 5, 423-428. https://doi.org/10.3892/etm.2012.853
MLA
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., Chen, L."Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB". Experimental and Therapeutic Medicine 5.2 (2013): 423-428.
Chicago
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., Chen, L."Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB". Experimental and Therapeutic Medicine 5, no. 2 (2013): 423-428. https://doi.org/10.3892/etm.2012.853
Copy and paste a formatted citation
x
Spandidos Publications style
Chu K, Zheng H, Li H, Zhang Y, Zhang X, Xu W and Chen L: Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB. Exp Ther Med 5: 423-428, 2013.
APA
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., & Chen, L. (2013). Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB. Experimental and Therapeutic Medicine, 5, 423-428. https://doi.org/10.3892/etm.2012.853
MLA
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., Chen, L."Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB". Experimental and Therapeutic Medicine 5.2 (2013): 423-428.
Chicago
Chu, K., Zheng, H., Li, H., Zhang, Y., Zhang, X., Xu, W., Chen, L."Shuangtengbitong tincture treatment of collagen‑induced arthritis via downregulation of the expression of IL-6, IL-8, TNF-α and NF-κB". Experimental and Therapeutic Medicine 5, no. 2 (2013): 423-428. https://doi.org/10.3892/etm.2012.853
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