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Article

The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma

  • Authors:
    • Hongsheng Lu
    • Zhaohui Yang
    • Hui Zhang
    • Meifu Gan
    • Tao Zhou
    • Siling Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Taizhou Central Hospital of Taizhou Enze Medical Group, Taizhou 318000, P.R. China, Department of Pathology, Taizhou Hospital of Taizhou Enze Medical Group, Linhai 317000, P.R. China
  • Pages: 890-896
    |
    Published online on: December 17, 2012
       https://doi.org/10.3892/etm.2012.859
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Abstract

Renal cell carcinoma (RCC) is one of the most common malignant neoplasms in the urinary system, and has a high frequency of local invasion and distant metastasis. This study assessed the expression and clinical significance of matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in human clear cell renal cell carcinoma (CCRCC) by tissue microarray, immunohistochemistry and RT-PCR analysis. The expression of MMP-7 in CCRCC tissues was significantly higher compared with that in the control group (CG) and TIMP-2 expression in CCRCC, by contrast, was lower compared with that in the CG. The expression of MMP-7 and TIMP-2 in the CCRCC tissues was significantly correlated with the pathological grade and clinical stage. Log-rank analyses indicated that upregulation of MMP-7 and downregulation of TIMP-2 expression may occur during the progression of CCRCC, and Cox multivariate survival rate analysis demonstrated that there was also a positive correlation between the pathological grade, clinical stage, MMP-7 expression and survival rate. Thus, MMP-7 is an independent prognostic factor and MMP-7 and TIMP-2 may serve as useful molecular markers for evaluating prognosis in CCRCC patients.
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1. 

Awakura Y, Ito N, Nakamura E, Takahashi T, Kotani H, Mikami Y, Manabe T, Kamoto T, Habuchi T and Ogawa O: Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population. Cancer Lett. 241:59–63. 2006. View Article : Google Scholar : PubMed/NCBI

2. 

Nagase H and Woessner JF: Matrix metalloproteinases. J Biol Chem. 274:21491–21494. 1999. View Article : Google Scholar

3. 

Declerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM and Muschel RJ: Proteases, extracellular matrix and cancer: a workshop of the path B study section. Am J Pathol. 164:1131–1139. 2004. View Article : Google Scholar : PubMed/NCBI

4. 

Di Nezza LA, Misajon A and Zhang J: Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion. Cancer. 94:1466–1475. 2002.

5. 

Egelblad M and Werb Z: New functions for the matrix metal-loproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

6. 

Jiang WG, Davies G, Martin TA, Parr C, Watkins G, Mason MD and Mansel RE: Expression of membrane type-1 matrix metal-loproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. Int J Mol Med. 17:583–590. 2006.PubMed/NCBI

7. 

Ogata Y, Miura K, Ohkita A, Nagase H and Shirouzu K: Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma. Kurume Med J. 48:211–218. 2001. View Article : Google Scholar

8. 

Moore CS and Crocker SJ: An alternate perspective on the roles of TIMPs and MMPs in pathology. Am J Pathol. 180:12–16. 2012. View Article : Google Scholar : PubMed/NCBI

9. 

Hahne JC, Fuchs T, El Mustapha H, Okuducu AF, Bories JC and Wernert N: Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts. Int J Mol Med. 18:153–159. 2006.PubMed/NCBI

10. 

Abdel-Wahed MM, Asaad NY and Aleskandarany M: Expression of matrix metalloproteinase-2 in renal cell carcinoma. J Egypt Natl Canc Inst. 16:168–177. 2004.PubMed/NCBI

11. 

Aoyama T, Yamamoto S, Kanematsu A, Ogawa O and Tabata Y: Local delivery of matrix metalloproteinase gene prevents the onset of renal sclerosis in streptozocin-induced diabetic mice. Tissue Eng. 9:1289–1296. 2003. View Article : Google Scholar : PubMed/NCBI

12. 

Hirata H, Naito K, Yoshihiro S, Matsuyama H, Suehiro Y and Hinoda Y: A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma. Int J Cancer. 106:372–374. 2003. View Article : Google Scholar : PubMed/NCBI

13. 

Hirata H, Okayama N, Naito K, Inoue R, Yoshihiro S, Matsuyama H, Suehiro Y, Hamanaka Y and Hinoda Y: Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma. Carcinogenesis. 25:2379–2384. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Huo N, Ichikawa Y and Kamiyama M: MMP-7 (matrilysin) accelerated growth of human umbilical vein endothelial cells. Cancer Lett. 177:95–100. 2002. View Article : Google Scholar : PubMed/NCBI

15. 

Miyata Y, Iwata T, Maruta S, Kanda S, Nishikido M, Koga S and Kanetake H: Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role. Eur Urol. 52:791–597. 2007. View Article : Google Scholar : PubMed/NCBI

16. 

Struckmann K, Mertz KD, Steu S, Storz M, Staller P, Krek W, Schraml P and Moch H: pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol. 214:464–471. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Yang SD, Sun RC, Mu HJ, Xu ZQ and Zhou ZY: The expression and clinical significance of TGF-β1 and MMP2 in human renal clear cell carcinoma. Int J Surg Pathol. 18:85–93. 2010.

18. 

Eble JN, Sauter G, Epstein JI and Sesterhenn IA: World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. IARC Press; Lyon, France: pp. 16–18. 2004

19. 

Lu H, Gan M, Zhang G, Zhou T, Yan M and Wang S: Expression of survivin, caspase-3 and p53 in cervical cancer assessed by tissue microarray: correlation with clinicopathology and prognosis. Eur J Gynaecol Oncol. 6:662–666. 2010.PubMed/NCBI

20. 

Johansson N, Ahonen M and Kahari VM: Matrix metalloproteinases in tumor invasion. Cell Mol Life Sci. 57:5–15. 2000. View Article : Google Scholar

21. 

Stetler-Stevenson WG, Liotta LA and Kleiner DE: Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. Faseb J. 7:1434–1441. 1993.PubMed/NCBI

22. 

Stetler-Stevenson WG and Yu AE: Proteases in invasion: matrix metalloproteinases. Semin Cancer Biol. 11:143–152. 2001. View Article : Google Scholar : PubMed/NCBI

23. 

Kawata N, Nagane Y, Hirakata H, Ichinose T, Okada Y, Yamaguchi K and Takahashi S: Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma. Urology. 69:1050–1053. 2007. View Article : Google Scholar

24. 

Kawata N, Nagane Y and Igarashi T: Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. Urology. 68:523–527. 2006. View Article : Google Scholar : PubMed/NCBI

25. 

Miyata Y, Iwata T, Ohba K, Kanda S, Nishikido M and Kanetake H: Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis. Clin Cancer Res. 12:6998–7003. 2006. View Article : Google Scholar

26. 

Kumaki F, Matsui K and Kawai T: Expression of matrix metal-loproteinases in invasive pulmonary adenocarcinoma with bronchioloalveolar component and atypical adenomatous hyperplasia. Am J Pathol. 159:2125–2135. 2001. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Yang Z, Zhang H, Gan M, Zhou T and Wang S: The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma. Exp Ther Med 5: 890-896, 2013.
APA
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., & Wang, S. (2013). The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma. Experimental and Therapeutic Medicine, 5, 890-896. https://doi.org/10.3892/etm.2012.859
MLA
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., Wang, S."The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma". Experimental and Therapeutic Medicine 5.3 (2013): 890-896.
Chicago
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., Wang, S."The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma". Experimental and Therapeutic Medicine 5, no. 3 (2013): 890-896. https://doi.org/10.3892/etm.2012.859
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Yang Z, Zhang H, Gan M, Zhou T and Wang S: The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma. Exp Ther Med 5: 890-896, 2013.
APA
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., & Wang, S. (2013). The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma. Experimental and Therapeutic Medicine, 5, 890-896. https://doi.org/10.3892/etm.2012.859
MLA
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., Wang, S."The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma". Experimental and Therapeutic Medicine 5.3 (2013): 890-896.
Chicago
Lu, H., Yang, Z., Zhang, H., Gan, M., Zhou, T., Wang, S."The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma". Experimental and Therapeutic Medicine 5, no. 3 (2013): 890-896. https://doi.org/10.3892/etm.2012.859
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