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Article

Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan

  • Authors:
    • Xiangjun Zeng
    • Xiangli Li
    • Xiaowei Xue
    • Zheng-Ming Shi
    • Ping Feng
    • Pengyan Wang
    • Xue-Jiang Wang
  • View Affiliations / Copyright

    Affiliations: Pathophysiological Department, Capital Medical University, Beijing 100069, P.R. China, Department of General Surgery, Beijing Jishuitan Hospital, Beijing 100035, P.R. China
  • Pages: 695-700
    |
    Published online on: December 18, 2012
       https://doi.org/10.3892/etm.2012.862
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Abstract

To investigate the effects of Hu Qisan (HQS) on apoptosis in diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC), a Solt-Farber two-step test model of precancerous liver lesions was established in rats using a previously described method. HQS (4 and 8 g/kg body weight/day) was administered for 4 weeks, after the majority of the liver was removed. HepG2 cells were used to detect the HtrA serine peptidase 2 (HtrA2/Omi) release from mitochondria and caspase-3 activation promoted by HQS. Exposure of the rats to DEN for 6 weeks induced hepatic carcinogenesis. HQS (4 and 8 g/kg body weight/day) markedly induced cell apoptosis. The protective effects against hepatic carcinogenesis were mediated by multiple mechanisms, including the reduction of DEN-induced γ-GT-positive cell proliferation, mitochondrial morphological changes, HtrA2/Omi release from mitochondria and the activation of caspase-3. In conclusion, HQS is a potential anti-carcinogenic agent that may induce apoptosis by reducing the inhibitory effects of X-linked inhibitor of apoptosis protein (XIAP) on caspase-3. Thus, HQS should be further explored as a potentially promising new therapeutic agent against human hepatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zeng X, Li X, Xue X, Shi Z, Feng P, Wang P and Wang X: Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan. Exp Ther Med 5: 695-700, 2013.
APA
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., & Wang, X. (2013). Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan. Experimental and Therapeutic Medicine, 5, 695-700. https://doi.org/10.3892/etm.2012.862
MLA
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., Wang, X."Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan". Experimental and Therapeutic Medicine 5.3 (2013): 695-700.
Chicago
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., Wang, X."Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan". Experimental and Therapeutic Medicine 5, no. 3 (2013): 695-700. https://doi.org/10.3892/etm.2012.862
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng X, Li X, Xue X, Shi Z, Feng P, Wang P and Wang X: Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan. Exp Ther Med 5: 695-700, 2013.
APA
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., & Wang, X. (2013). Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan. Experimental and Therapeutic Medicine, 5, 695-700. https://doi.org/10.3892/etm.2012.862
MLA
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., Wang, X."Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan". Experimental and Therapeutic Medicine 5.3 (2013): 695-700.
Chicago
Zeng, X., Li, X., Xue, X., Shi, Z., Feng, P., Wang, P., Wang, X."Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan". Experimental and Therapeutic Medicine 5, no. 3 (2013): 695-700. https://doi.org/10.3892/etm.2012.862
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