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Article

Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis

  • Authors:
    • Lian Gu
    • Li Su
    • Qing Chen
    • Baoyun Liang
    • Yuwang Qin
    • Juanjuan  Xie
    • Guangliang Wu
    • Yan Yan
    • Jianxiong Long
    • Huayu Wu
    • Jinjing  Tan
    • Weihua Dou
    • Wei Chen
    • Peng Wu
    • Jinping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, P.R. China, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China, School of Basic Medicine, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 853-859
    |
    Published online on: December 19, 2012
       https://doi.org/10.3892/etm.2012.866
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Abstract

Ischemic stroke (IS) is a complex multifactorial inherited disease. Many studies have focused on the potential genetic effects of apolipoprotein E (ApoE) gene polymorphism on IS. However, inconsistencies still exist in the association of ApoE gene polymorphism with IS. The aim of this study was to investigate the ApoE gene polymorphism in relation to IS in the Guangxi Han populations and assess the risk of various ApoE genotypes associated with IS in Chinese populations. We conducted a case-control study involving a total of 166 IS cases and 192 healthy controls to investigate the association of ApoE gene polymorphism with IS in the Guangxi Han populations. Furthermore, we performed a meta-analysis to investigate whether the ApoE gene polymorphism is associated with IS in Chinese populations. There was no evidence for a significant association between ApoE gene polymorphism and IS in the Guangxi Han populations (ε2/ε2 vs. ε3/ε3: OR=1.25, 95% CI=0.08-20.17; ε2/ε3 vs. ε3/ε3: OR=1.49, 95% CI=0.79‑2.79; ε2/ε4 vs. ε3/ε3: OR=1.25, 95% CI=0.17‑9.00; ε3/ε4 vs. ε3/ε3: OR=1.10, 95% CI=0.60‑2.04; ε4/ε4 vs. ε3/ε3: OR=2.50, 95% CI=0.22‑27.87; allele ε2 vs. allele ε3: OR=1.39, 95% CI=0.80-2.44; allele ε4 vs. allele ε3: OR=1.16, 95% CI=0.68-1.98). In our meta-analysis, a significant association of ApoE gene polymorphism with IS was found in the genetic model of ε2/ε4 vs. ε3/ε3 (OR=2.04, 95% CI=1.45‑2.85), ε3/ε4 vs. ε3/ε3 (OR=1.93, 95% CI=1.42-2.62), ε4/ε4 vs. ε3/ε3 (OR=3.41, 95% CI=2.17-5.34) and allele ε4 vs. allele ε3 (OR=2.34, 95% CI=1.91-2.86). However, no clear associations were found in the model of ε2/ε2 vs. ε3/ε3 (OR=1.56, 95% CI=0.90‑2.71), ε2/ε3 vs. ε3/ε3 (OR=0.93, 95% CI=0.79‑1.09) and allele ε2 vs. allele ε3 (OR=1.10, 95% CI=0.97-1.25). In conclusion, no association was found between ApoE gene polymorphism and IS in the Guangxi Han populations, while the results of the meta-analysis indicate that the ApoE mutation allele ε4 increases the risk of IS in Chinese populations.
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Copy and paste a formatted citation
Spandidos Publications style
Gu L, Su L, Chen Q, Liang B, Qin Y, Xie J, Wu G, Yan Y, Long J, Wu H, Wu H, et al: Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis. Exp Ther Med 5: 853-859, 2013.
APA
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J. ... Wang, J. (2013). Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis. Experimental and Therapeutic Medicine, 5, 853-859. https://doi.org/10.3892/etm.2012.866
MLA
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J., Wu, G., Yan, Y., Long, J., Wu, H., Tan, J., Dou, W., Chen, W., Wu, P., Wang, J."Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis". Experimental and Therapeutic Medicine 5.3 (2013): 853-859.
Chicago
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J., Wu, G., Yan, Y., Long, J., Wu, H., Tan, J., Dou, W., Chen, W., Wu, P., Wang, J."Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis". Experimental and Therapeutic Medicine 5, no. 3 (2013): 853-859. https://doi.org/10.3892/etm.2012.866
Copy and paste a formatted citation
x
Spandidos Publications style
Gu L, Su L, Chen Q, Liang B, Qin Y, Xie J, Wu G, Yan Y, Long J, Wu H, Wu H, et al: Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis. Exp Ther Med 5: 853-859, 2013.
APA
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J. ... Wang, J. (2013). Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis. Experimental and Therapeutic Medicine, 5, 853-859. https://doi.org/10.3892/etm.2012.866
MLA
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J., Wu, G., Yan, Y., Long, J., Wu, H., Tan, J., Dou, W., Chen, W., Wu, P., Wang, J."Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis". Experimental and Therapeutic Medicine 5.3 (2013): 853-859.
Chicago
Gu, L., Su, L., Chen, Q., Liang, B., Qin, Y., Xie, J., Wu, G., Yan, Y., Long, J., Wu, H., Tan, J., Dou, W., Chen, W., Wu, P., Wang, J."Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysis". Experimental and Therapeutic Medicine 5, no. 3 (2013): 853-859. https://doi.org/10.3892/etm.2012.866
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