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Review

Targeting CD83 for the treatment of graft-versus-host disease (Review)

  • Authors:
    • Xiongfei Wang
    • Ming Q. Wei
    • Xiaosong Liu
  • View Affiliations / Copyright

    Affiliations: Division of Molecular and Gene Therapies, Griffith Health Institute and School of Medical Science, Griffith University, Gold Coast, Queensland 4222, Australia, Cancer Research Institute, Foshan First People's Hospital, Foshan, Guangdong 528000, P.R. China
  • Pages: 1545-1550
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    Published online on: April 2, 2013
       https://doi.org/10.3892/etm.2013.1033
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Abstract

Graft-versus-host disease (GVHD) is a common and often fatal complication of bone marrow transplantation. Antigen-presenting cells from donor and recipient play a critical role in the initiation and maintenance of GVHD. CD83, which is expressed in activated lymphocytes and dendritic cells, is regarded as a marker of mature dendritic cells. Targeting CD83 using soluble CD83 molecules or antibodies has been demonstrated to have therapeutic effects against GVHD in preclinical models. Understanding the biological function of CD83 and the underlying mechanisms through which targeting CD83 attenuates GVHD is likely to greatly improve current treatments and provide new methods for the treatment of GVHD.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wei MQ and Liu X: Targeting CD83 for the treatment of graft-versus-host disease (Review). Exp Ther Med 5: 1545-1550, 2013.
APA
Wang, X., Wei, M.Q., & Liu, X. (2013). Targeting CD83 for the treatment of graft-versus-host disease (Review). Experimental and Therapeutic Medicine, 5, 1545-1550. https://doi.org/10.3892/etm.2013.1033
MLA
Wang, X., Wei, M. Q., Liu, X."Targeting CD83 for the treatment of graft-versus-host disease (Review)". Experimental and Therapeutic Medicine 5.6 (2013): 1545-1550.
Chicago
Wang, X., Wei, M. Q., Liu, X."Targeting CD83 for the treatment of graft-versus-host disease (Review)". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1545-1550. https://doi.org/10.3892/etm.2013.1033
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wei MQ and Liu X: Targeting CD83 for the treatment of graft-versus-host disease (Review). Exp Ther Med 5: 1545-1550, 2013.
APA
Wang, X., Wei, M.Q., & Liu, X. (2013). Targeting CD83 for the treatment of graft-versus-host disease (Review). Experimental and Therapeutic Medicine, 5, 1545-1550. https://doi.org/10.3892/etm.2013.1033
MLA
Wang, X., Wei, M. Q., Liu, X."Targeting CD83 for the treatment of graft-versus-host disease (Review)". Experimental and Therapeutic Medicine 5.6 (2013): 1545-1550.
Chicago
Wang, X., Wei, M. Q., Liu, X."Targeting CD83 for the treatment of graft-versus-host disease (Review)". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1545-1550. https://doi.org/10.3892/etm.2013.1033
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