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Article

Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support

  • Authors:
    • Funda Satir
    • Tayfun Toptas
    • Murat Inel
    • Munire Erman-Akar
    • Omur Taskin
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynaecology, Akdeniz University Hospital, Antalya 07070, Turkey
  • Pages: 1740-1744
    |
    Published online on: April 4, 2013
       https://doi.org/10.3892/etm.2013.1049
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Abstract

The main objective of this study was to compare the pregnancy rates of intramuscular (IM) 17-α-hydroxyprogesterone caproate (17-HPC) and intravaginal (IV) progesterone gel administration in in vitro fertilization‑embryo transfer (IVF‑ET) cycles. The IM 17-HPC and IV progesterone groups included 632 (66.4%) and 320 (33.6%) women undergoing the first cycles of IVF-ET treatment, respectively. Multivariate analyses annotated for all potential confounders showed that the use of IV progesterone retained a predictive value for the total β-human chorionic gonadotropin (hCG) positivity and clinical pregnancy rates [adjusted odds ratio (OR), 1.97; 95% confidence interval (CI), 1.28-3.03; P=0.002; and OR, 1.66; 95% CI, 1.07‑2.60; P=0.03, respectively]. However, biochemical and on-going pregnancy rates did not differ significantly between the groups (OR, 1.85; 95% CI, 1.00‑3.41; P=0.05; and OR, 1.43, 95% CI, 0.89‑2.30; P=0.14, respectively). Luteal phase support (LPS) with IV progesterone gel in comparison with IM 17-HPC appears to be associated with higher clinical pregnancy rates in IVF-ET cycles. However, this benefit is clinically irrelevant in terms of on-going pregnancy outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Satir F, Toptas T, Inel M, Erman-Akar M and Taskin O: Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support. Exp Ther Med 5: 1740-1744, 2013.
APA
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., & Taskin, O. (2013). Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support. Experimental and Therapeutic Medicine, 5, 1740-1744. https://doi.org/10.3892/etm.2013.1049
MLA
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., Taskin, O."Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support". Experimental and Therapeutic Medicine 5.6 (2013): 1740-1744.
Chicago
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., Taskin, O."Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1740-1744. https://doi.org/10.3892/etm.2013.1049
Copy and paste a formatted citation
x
Spandidos Publications style
Satir F, Toptas T, Inel M, Erman-Akar M and Taskin O: Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support. Exp Ther Med 5: 1740-1744, 2013.
APA
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., & Taskin, O. (2013). Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support. Experimental and Therapeutic Medicine, 5, 1740-1744. https://doi.org/10.3892/etm.2013.1049
MLA
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., Taskin, O."Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support". Experimental and Therapeutic Medicine 5.6 (2013): 1740-1744.
Chicago
Satir, F., Toptas, T., Inel, M., Erman-Akar, M., Taskin, O."Comparison of intravaginal progesterone gel and intramuscular 17‑α‑hydroxyprogesterone caproate in luteal phase support". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1740-1744. https://doi.org/10.3892/etm.2013.1049
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