Specificity of anti‑SSB as a diagnostic marker for the classification of systemic lupus erythematosus

  • Authors:
    • Li Rao
    • Guiyan Liu
    • Chunfen Li
    • Yajuan Li
    • Zhiguo Wang
    • Zijiao Zhou
    • Shengquan Tong
    • Xianming Wu
  • View Affiliations

  • Published online on: April 8, 2013     https://doi.org/10.3892/etm.2013.1051
  • Pages: 1710-1714
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Abstract

The aim of the present study was to investigate the sensitivity and specificity of anti‑Sjögren's syndrome type B (SSB) antibodies for diagnosing systemic lupus erythematosus (SLE) and to understand the correlation between anti‑SSB antibodies and the clinical manifestations of SLE. A line immunoassay (LIA) was used to detect the presence of serum anti‑SSB antibodies in SLE patients. The clinical manifestations of the patients were recorded to enable their correlation with the serum anti‑SSB antibodies to be analyzed. In 25.7% of the 74 SLE patients, the serum was positive for anti‑SSB antibodies, whereas only 3.3% of the 30 control cases were positive. The specificity of anti‑SSB antibodies for detecting SLE was 96.7%. In anti‑SSB antibody‑positive SLE patients, the incidence of cheek erythema, alopecia, serositis, secondary Sjögren's syndrome (sSS), leukocytopenia, elevated immunoglobulin (Ig)G and positive presence of anti‑Sjögren's syndrome type A (SSA)60 or anti‑SSA52 antibodies was higher than in the anti‑SSB antibody‑negative group (P<0.05). Anti‑SSB antibodies are important for the diagnosis of SLE and are associated with cheek erythema, alopecia, serositis, sSS, leukocytopenia, the elevation of IgG and positive presence of anti‑SSA60 or anti‑SSA52 antibodies.
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June 2013
Volume 5 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Rao L, Liu G, Li C, Li Y, Wang Z, Zhou Z, Tong S and Wu X: Specificity of anti‑SSB as a diagnostic marker for the classification of systemic lupus erythematosus. Exp Ther Med 5: 1710-1714, 2013
APA
Rao, L., Liu, G., Li, C., Li, Y., Wang, Z., Zhou, Z. ... Wu, X. (2013). Specificity of anti‑SSB as a diagnostic marker for the classification of systemic lupus erythematosus. Experimental and Therapeutic Medicine, 5, 1710-1714. https://doi.org/10.3892/etm.2013.1051
MLA
Rao, L., Liu, G., Li, C., Li, Y., Wang, Z., Zhou, Z., Tong, S., Wu, X."Specificity of anti‑SSB as a diagnostic marker for the classification of systemic lupus erythematosus". Experimental and Therapeutic Medicine 5.6 (2013): 1710-1714.
Chicago
Rao, L., Liu, G., Li, C., Li, Y., Wang, Z., Zhou, Z., Tong, S., Wu, X."Specificity of anti‑SSB as a diagnostic marker for the classification of systemic lupus erythematosus". Experimental and Therapeutic Medicine 5, no. 6 (2013): 1710-1714. https://doi.org/10.3892/etm.2013.1051