A study of the relationship between the Wnt/β‑catenin signaling pathway and the gastrointestinal development of rat embryonic and perinatal periods

Wei,Botao; Guo,Yongsheng; Zhai,Jia; Su,Juan; Han,Lei; Kang,Chunsheng; Zhang,Qingyu

doi:10.3892/etm.2013.1058

A study of the relationship between the Wnt/β‑catenin signaling pathway and the gastrointestinal development of rat embryonic and perinatal periods

Authors:
- Botao Wei
- Yongsheng Guo
- Jia Zhai
- Juan Su
- Lei Han
- Chunsheng Kang
- Qingyu Zhang
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Affiliations: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Infectious Disease, Tianjin Children's Hospital, Tianjin 300052, P.R. China, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post‑trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, P.R. China
Published online on: April 9, 2013 https://doi.org/10.3892/etm.2013.1058
Pages: 1598-1602

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Abstract

The Wnt/β-catenin signaling pathway plays a critical role in directing cell fate during the embryonic development of animals and humans. To investigate the effects of the Wnt/β-catenin signaling pathway on gastrointestinal development and differentiation, we studied the expression pattern of β-catenin, a key component of the pathway, in the gastrointestinal tissues of embryonic and perinatal rats. Immunohistochemistry was used to examine the expression levels of β-catenin in Sprague Dawley (SD) rat embryos at days 13, 18 and 21 and in SD rats at 1, 3, 7 and 28 days of age. We observed that the expression of β-catenin was greater and more diffuse in the gastrointestinal tissues of rat embryos at days 18 and 21 of gestation and in SD rats at days 1 and 3. In conclusion, our data suggest that β-catenin also plays an important role in the development of gastrointestinal tissues during the middle and late embryonic periods and the early postnatal period.

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