Pituitary hormone level changes and hyponatremia in aneurysmal subarachnoid hemorrhage

Maimaitili,Aisha; Maimaitili,Mijiti; Rexidan,Aikeremu; Lu,Junyi; Ajimu,Kuerban; Cheng,Xiaojiang; Luo,Kun; Sailike,Duishanbai; Liu,Yuan; Kaheerman,Kadeer; Tang,Changjiu; Zhang,Tingrong

doi:10.3892/etm.2013.1068

June 2013 Volume 5 Issue 6

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June 2013 Volume 5 Issue 6

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Article

Pituitary hormone level changes and hyponatremia in aneurysmal subarachnoid hemorrhage

Authors:
- Aisha Maimaitili
- Mijiti Maimaitili
- Aikeremu Rexidan
- Junyi Lu
- Kuerban Ajimu
- Xiaojiang Cheng
- Kun Luo
- Duishanbai Sailike
- Yuan Liu
- Kadeer Kaheerman
- Changjiu Tang
- Tingrong Zhang
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
Pages: 1657-1662
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Published online on: April 18, 2013

https://doi.org/10.3892/etm.2013.1068
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Abstract

The aim of this study was to investigate the changes in serum pituitary hormone levels and the mechanism of hyponatremia in aneurysmal subarachnoid hemorrhage (SAH). Nuclear medical tests and serum electrolyte monitoring were performed in 49 aneurysmal SAH cases and 10 healthy volunteers. The levels of serum pituitary hormones were significantly higher in the SAH patients compared with the control group on days 1-3 and 7-9 after SAH onset (P<0.05). The peak value occurred on days 7-9. The rate of hyponatremia was 49.0% in the 49 SAH patients. The incidence of severe hyponatremia was significantly higher in Fisher grades III-IV and Hunt-Hess grades III-IV compared with Fisher grades I-II and Hunt-Hess grades I-II, respectively (P<0.05). There was no correlation between the site of aneurysm and the rate of hyponatremia. The incidence of symptomatic cerebral vasospasm was significantly higher in the hyponatremia group and Fisher grades III-IV compared with the normal serum sodium group and Fisher grades I-II, respectively. Serum pituitary hormone levels were positively correlated with blood loss and disease severity in patients with aneurysmal SAH. Hyponatremia may be considered an important indicator of SAH. SAH patients are likely to benefit from intense monitoring and regulation of serum sodium.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pituitary hormone level changes and hyponatremia in aneurysmal subarachnoid hemorrhage

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