Clinical values of urinary IL-6 in asymptomatic renal hematuria and renal hematuria with proteins

Song,Minghui; Ma,Lu; Yang,Dan; He,Zhijun; Li,Chaobo; Pan,Tao; Li,Anjun

doi:10.3892/etm.2013.1124

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Article

Clinical values of urinary IL-6 in asymptomatic renal hematuria and renal hematuria with proteins

Authors:
- Minghui Song
- Lu Ma
- Dan Yang
- Zhijun He
- Chaobo Li
- Tao Pan
- Anjun Li
View Affiliations / Copyright

Affiliations: Integrated Chinese and Western Medicine Treatment of Renal Disease Centre, Beidaihe Sanatorium of Beijing Military Area Command, Qinhuangdao, Hebei 066100, P.R. China
Pages: 396-400
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Published online on: May 20, 2013

https://doi.org/10.3892/etm.2013.1124
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Abstract

Renal hematuria is caused by glomerular disease. Under pathological conditions, the distribution of interleukin-6 (IL-6) in kidney tissue is abnormal and urinary IL-6 levels are increased. Abnormal IL-6 secretion promotes the hyperplasia of mesangial cells and matrix and, thus, affects the permeability of the glomerular filtration membrane. Therefore, the detection of urinary IL-6 levels in patients with renal hematuria is beneficial for disease evaluation. A total of 82 patients with primary renal hematuria were divided into group 1 (UPr/24 h < 150 mg; pure hematuria group), group 2 (150 mg ≤ UPr/24 h ≤ 1,000 mg) and group 3 (UPr/24 h > 1,000 mg). A total of 30 normal individuals were selected as the controls. The urinary IL-6 levels were detected by the enzyme-linked immunosorbent assay (ELISA) method and a renal biopsy was conducted. The urinary IL-6 levels and renal pathological damage scores in groups 1 and 2 were significantly reduced compared with those in group 3, (P<0.001 and 0.01, respectively), with no significant difference between groups 1 and 2 (P>0.05). The correlation coefficient (r) of urinary IL-6 with 24 h urinary protein (UPr/24 h) in groups 1, 2 and 3 was 0.017, 0.045 and 0.747, respectively, and that of urinary IL-6 with renal pathological damage score was 0.627, 0.199 and 0.119, respectively. The UPr/24 h was significantly correlated with IL-6 level (r=0.7320, P<0.000). In group 1, the urinary IL-6 levels were correlated with the degree of renal pathological damage. A positive correlation was observed between urinary IL-6 levels and UPr/24 h.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical values of urinary IL-6 in asymptomatic renal hematuria and renal hematuria with proteins

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