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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August 2013 Volume 6 Issue 2

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Article

Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients

  • Authors:
    • Lihua Shi
    • Jie Song
    • Xiaodong Zhang
    • Ying Li
    • Hui Li
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China
  • Pages: 532-536
    |
    Published online on: May 28, 2013
       https://doi.org/10.3892/etm.2013.1131
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Abstract

The aim of this study was to examine the correlation between the microinflammatory state and structural and functional changes of the left ventricle in maintenance haemodialysis patients (MHD). In total, 48 MHD patients and 30 healthy volunteers participated in this study. The microinflammatory state was detected from high‑sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) levels determined by ELISA. The structure and function of the left ventricle was measured according to ultrasound cardiogram examination. The serum levels of hs-CRP, IL-6 and TNF-α in the MHD patients were higher compared with those in the controls (P<0.05). Furthermore, the measurements of the left atrial diameter (LAD), left venticular diameter (LVD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) and the left ventricular mass index (LVMI) increased significantly and the left ventricular function (LVEF) was reduced. Correlation analysis demonstrated that the concentrations of hs-CRP, TNF-α and IL-6 correlated with the LVMI (P<0.05), but only hs-CRP correlated with the loss of function of the heart in the haemodialysis patients (P<0.05). The microinflammatory state may be closely associated with the structural and functional impairment of the heart in MHD patients.
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Copy and paste a formatted citation
Spandidos Publications style
Shi L, Song J, Zhang X, Li Y and Li H: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. Exp Ther Med 6: 532-536, 2013.
APA
Shi, L., Song, J., Zhang, X., Li, Y., & Li, H. (2013). Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. Experimental and Therapeutic Medicine, 6, 532-536. https://doi.org/10.3892/etm.2013.1131
MLA
Shi, L., Song, J., Zhang, X., Li, Y., Li, H."Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients". Experimental and Therapeutic Medicine 6.2 (2013): 532-536.
Chicago
Shi, L., Song, J., Zhang, X., Li, Y., Li, H."Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients". Experimental and Therapeutic Medicine 6, no. 2 (2013): 532-536. https://doi.org/10.3892/etm.2013.1131
Copy and paste a formatted citation
x
Spandidos Publications style
Shi L, Song J, Zhang X, Li Y and Li H: Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. Exp Ther Med 6: 532-536, 2013.
APA
Shi, L., Song, J., Zhang, X., Li, Y., & Li, H. (2013). Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients. Experimental and Therapeutic Medicine, 6, 532-536. https://doi.org/10.3892/etm.2013.1131
MLA
Shi, L., Song, J., Zhang, X., Li, Y., Li, H."Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients". Experimental and Therapeutic Medicine 6.2 (2013): 532-536.
Chicago
Shi, L., Song, J., Zhang, X., Li, Y., Li, H."Correlation between the microinflammatory state and left ventricular structural and functional changes in maintenance haemodialysis patients". Experimental and Therapeutic Medicine 6, no. 2 (2013): 532-536. https://doi.org/10.3892/etm.2013.1131
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