Epidermal barrier: Adverse and beneficial changes induced by ultraviolet B irradiation depending on the exposure dose and time (Review)

Permatasari,Felicia; Zhou,Bingrong; Luo,Dan

doi:10.3892/etm.2013.1175

August 2013 Volume 6 Issue 2

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August 2013 Volume 6 Issue 2

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Review

Epidermal barrier: Adverse and beneficial changes induced by ultraviolet B irradiation depending on the exposure dose and time (Review)

Authors:
- Felicia Permatasari
- Bingrong Zhou
- Dan Luo
View Affiliations / Copyright

Affiliations: Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
Pages: 287-292
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Published online on: June 21, 2013

https://doi.org/10.3892/etm.2013.1175
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Abstract

Exposure of the skin to ultraviolet (UV) radiation induces various harmful effects in the tissues, particularly disruption of the epidermal barrier. However, ultraviolet B (UVB) irradiation has been applied in the treatment of atopic dermatitis, a skin disease in which the epidermal barrier is defective. We reviewed the homeostasis of the epidermal barrier and several studies investigating the adverse and beneficial effects caused by different doses of UVB irradiation in the epidermal barrier. It may be concluded that, despite the harmful effects of UVB irradiation on the skin, UVB irradiation is able to exert beneficial effects in the epidermal barrier when administered in suberythemal doses and over a relatively short period of time, with no clinically evident inflammation or barrier disruption. This may be a useful therapeutic strategy for the use of UVB irradiation in the treatment of skin diseases with a disrupted epidermal barrier, such as atopic dermatitis, while reducing or avoiding the side‑effects.

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1.	Herrling T, Jung K and Fuchs J: Measurements of UV-generated free radicals/reactive oxygen species (ROS) in skin. Spectrochim Acta A Mol Biomol Spectrosc. 63:840–845. 2006. View Article : Google Scholar : PubMed/NCBI
2.	Haywood R, Rogge F and Lee M: Protein, lipid, and DNA radicals to measure skin UVA damage and modulation by melanin. Free Radic Biol Med. 44:990–1000. 2008. View Article : Google Scholar : PubMed/NCBI
3.	Bak H, Hong SP, Jeong SK, et al: Altered epidermal lipid layers induced by long-term exposure to suberythemal-dose ultraviolet. Int J Dermatol. 50:832–837. 2011. View Article : Google Scholar : PubMed/NCBI
4.	McAuliffe DJ and Blank IH: Effects of UVA (320–400 nm) on the barrier characteristics of the skin. J Invest Dermatol. 96:758–762. 1991.
5.	Abe T and Mayuzumi J: The change and recovery of human skin barrier functions after ultraviolet light irradiation. Chem Pharm Bull (Tokyo). 27:458–462. 1979. View Article : Google Scholar : PubMed/NCBI
6.	Solomon AE and Lowe NJ: Percutaneous absorption in experimental epidermal disease. Br J Dermatol. 100:717–722. 1979. View Article : Google Scholar : PubMed/NCBI
7.	Lamaud E and Schalla W: Influence of UV irradiation on penetration of hydrocortisone. In vivo study in hairless rat skin. Br J Dermatol. 111(Suppl 27): S152–S157. 1984. View Article : Google Scholar : PubMed/NCBI
8.	Valkova S and Velkova A: UVA/UVB phototherapy for atopic dermatitis revisited. J Dermatolog Treat. 15:239–244. 2004. View Article : Google Scholar : PubMed/NCBI
9.	Jekler J and Larkö O: UVB phototherapy of atopic dermatitis. Br J Dermatol. 119:697–705. 1988. View Article : Google Scholar : PubMed/NCBI
10.	Wulf HC and Bech-Thomsen N: A UVB phototherapy protocol with very low dose increments as a treatment of atopic dermatitis. Photodermatol Photoimmunol Photomed. 14:1–6. 1998. View Article : Google Scholar : PubMed/NCBI
11.	Elias PM: The stratum corneum as an organ of protection: old and new concepts. Curr Probl Dermatol. 18:10–21. 1989.PubMed/NCBI
12.	Feingold KR: Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis. J Lipid Res. 48:2531–2546. 2007. View Article : Google Scholar : PubMed/NCBI
13.	Proksch E, Brandner JM and Jensen JM: The skin: an indispensable barrier. Exp Dermatol. 17:1063–1072. 2008. View Article : Google Scholar : PubMed/NCBI
14.	Nilsson GE: Measurement of water exchange through skin. Med Biol Eng Comput. 15:209–218. 1977. View Article : Google Scholar : PubMed/NCBI
15.	Pinnagoda J, Tupker RA, Agner T and Serup J: Guidelines for transepidermal water loss (TEWL) measurement. A report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis. 22:164–178. 1990. View Article : Google Scholar : PubMed/NCBI
16.	Elias PM and Feingold KR: Skin Barrier. Taylor & Francis; New York: 2006
17.	Wertz PW: Epidermal lipids. Semin Dermatol. 11:106–113. 1992.
18.	Rassner U, Feingold KR, Crumrine DA and Elias PM: Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies. Tissue Cell. 31:489–498. 1999. View Article : Google Scholar : PubMed/NCBI
19.	Menon GK, Grayson S and Elias PM: Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol. 84:508–512. 1985. View Article : Google Scholar : PubMed/NCBI
20.	Menon GK, Elias PM, Lee SH and Feingold KR: Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tissue Res. 270:503–512. 1992. View Article : Google Scholar : PubMed/NCBI
21.	Menon GK and Elias PM: Ultrastructural localization of calcium in psoriatic and normal human epidermis. Arch Dermatol. 127:57–63. 1991. View Article : Google Scholar : PubMed/NCBI
22.	Freinkel RK and Traczyk TN: Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis. J Invest Dermatol. 85:295–298. 1985. View Article : Google Scholar : PubMed/NCBI
23.	Grayson S, Johnson-Winegar AG, Wintroub BU, Isseroff RR, Epstein EH Jr and Elias PM: Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization. J Invest Dermatol. 85:289–294. 1985. View Article : Google Scholar : PubMed/NCBI
24.	Wertz PW, Downing DT, Freinkel RK and Traczyk TN: Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. J Invest Dermatol. 83:193–195. 1984. View Article : Google Scholar : PubMed/NCBI
25.	Holleran WM, Ginns EI, Menon GK, et al: Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest. 93:1756–1764. 1994. View Article : Google Scholar
26.	Holleran WM, Takagi Y, Menon GK, Legler G, Feingold KR and Elias PM: Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest. 91:1656–1664. 1993. View Article : Google Scholar : PubMed/NCBI
27.	Hedberg CL, Wertz PW and Downing DT: The time course of lipid biosynthesis in pig epidermis. J Invest Dermatol. 91:169–174. 1988. View Article : Google Scholar : PubMed/NCBI
28.	Swartzendruber DC, Wertz PW, Madison KC and Downing DT: Evidence that the corneocyte has a chemically bound lipid envelope. J Invest Dermatol. 88:709–713. 1987. View Article : Google Scholar
29.	Wertz PW, Madison KC and Downing DT: Covalently bound lipids of human stratum corneum. J Invest Dermatol. 92:109–111. 1989. View Article : Google Scholar : PubMed/NCBI
30.	Marekov LN and Steinert PM: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. J Biol Chem. 273:17763–17770. 1998. View Article : Google Scholar : PubMed/NCBI
31.	Behne M, Uchida Y, Seki T, de Montellano PO, Elias PM and Holleran WM: Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol. 114:185–192. 2000. View Article : Google Scholar
32.	Nemes Z, Marekov LN, Fésüs L and Steinert PM: A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation. Proc Natl Acad Sci USA. 96:8402–8407. 1999. View Article : Google Scholar : PubMed/NCBI
33.	Fitzpatrick TB, Eisen AZ, Wolff K, Freedburg IM and Austen KF: Dermatology in General Medicine. 4th edition. McGraw-Hill, Health Professions Division; New York: 1993
34.	Cole CA, Forbes PD and Davies RE: An action spectrum for UV photocarcinogenesis. Photochem Photobiol. 43:275–284. 1986. View Article : Google Scholar : PubMed/NCBI
35.	Sterenborg HJ, de Gruijl FR, Kelfkens G and van der Leun JC: Evaluation of skin cancer risk resulting from long term occupational exposure to radiation from ultraviolet lasers in the range from 190 to 400 nm. Photochem Photobiol. 54:775–780. 1991. View Article : Google Scholar : PubMed/NCBI
36.	Bissett DL, Hannon DP and Orr TV: Wavelength dependence of histological, physical, and visible changes in chronically UV-irradiated hairless mouse skin. Photochem Photobiol. 50:763–769. 1989. View Article : Google Scholar : PubMed/NCBI
37.	Haratake A, Uchida Y, Schmuth M, et al: UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response. J Invest Dermatol. 108:769–775. 1997. View Article : Google Scholar : PubMed/NCBI
38.	Takagi Y, Nakagawa H, Kondo H, Takema Y and Imokawa G: Decreased levels of covalently bound ceramide are associated with ultraviolet B-induced perturbation of the skin barrier. J Invest Dermatol. 123:1102–1109. 2004. View Article : Google Scholar : PubMed/NCBI
39.	Meguro S, Arai Y, Masukawa Y, Uie K and Tokimitsu I: Relationship between covalently bound ceramides and transepidermal water loss (TEWL). Arch Dermatol Res. 292:463–468. 2000. View Article : Google Scholar : PubMed/NCBI
40.	Bernerd F and Asselineau D: Successive alteration and recovery of epidermal differentiation and morphogenesis after specific UVB-damages in skin reconstructed in vitro. Dev Biol. 183:123–138. 1997. View Article : Google Scholar : PubMed/NCBI
41.	Hirao T, Denda M and Takahashi M: Identification of immature cornified envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components. Exp Dermatol. 10:35–44. 2001. View Article : Google Scholar : PubMed/NCBI
42.	Proksch E, Holleran WM, Menon GK, Elias PM and Feingold KR: Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol. 128:473–482. 1993. View Article : Google Scholar : PubMed/NCBI
43.	Grubauer G, Elias PM and Feingold KR: Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res. 30:323–333. 1989.
44.	Menon GK, Feingold KR, Mao-Qiang M, Schaude M and Elias PM: Structural basis for the barrier abnormality following inhibition of HMG CoA reductase in murine epidermis. J Invest Dermatol. 98:209–219. 1992. View Article : Google Scholar : PubMed/NCBI
45.	Meguro S, Arai Y, Masukawa K, Uie K and Tokimitsu I: Stratum corneum lipid abnormalities in UVB-irradiated skin. Photochem Photobiol. 69:317–321. 1999. View Article : Google Scholar : PubMed/NCBI
46.	Wertz PW and Downing DT: Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. Biochim Biophys Acta. 917:108–111. 1987. View Article : Google Scholar : PubMed/NCBI
47.	Abraham W and Downing DT: Interaction between corneocytes and stratum corneum lipid liposomes in vitro. Biochim Biophys Acta. 1021:119–125. 1990. View Article : Google Scholar : PubMed/NCBI
48.	Chang F, Swartzendruber DC, Wertz PW and Squier CA: Covalently bound lipids in keratinizing epithelia. Biochim Biophys Acta. 1150:98–102. 1993. View Article : Google Scholar : PubMed/NCBI
49.	Takagi Y, Nakagawa H, Yaginuma T, Takema Y and Imokawa G: An accumulation of glucosylceramide in the stratum corneum due to attenuated activity of beta-glucocerebrosidase is associated with the early phase of UVB-induced alteration in cutaneous barrier function. Arch Dermatol Res. 297:18–25. 2005. View Article : Google Scholar : PubMed/NCBI
50.	Haratake A, Uchida Y, Mimura K, Elias PM and Holleran WM: Intrinsically aged epidermis displays diminished UVB-induced alterations in barrier function associated with decreased proliferation. J Invest Dermatol. 108:319–323. 1997. View Article : Google Scholar : PubMed/NCBI
51.	Marsh NL, Elias PM and Holleran WM: Glucosylceramides stimulate murine epidermal hyperproliferation. J Clin Invest. 95:2903–2909. 1995. View Article : Google Scholar : PubMed/NCBI
52.	Takagi Y, Kriehuber E, Imokawa G, Elias PM and Holleran WM: Beta-glucocerebrosidase activity in mammalian stratum corneum. J Lipid Res. 40:861–869. 1999.PubMed/NCBI
53.	Hamanaka S, Hara M, Nishio H, Otsuka F, Suzuki A and Uchida Y: Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol. 119:416–423. 2002. View Article : Google Scholar : PubMed/NCBI
54.	Uchida Y, Hara M, Nishio H, et al: Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res. 41:2071–2082. 2000.PubMed/NCBI
55.	Jiang SJ, Chu AW, Lu ZF, Pan MH, Che DF and Zhou XJ: Ultraviolet B-induced alterations of the skin barrier and epidermal calcium gradient. Exp Dermatol. 16:985–992. 2007. View Article : Google Scholar : PubMed/NCBI
56.	Lee SH, Elias PM, Proksch E, Menon GK, Mao-Quiang M and Feingold KR: Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J Clin Invest. 89:530–538. 1992. View Article : Google Scholar : PubMed/NCBI
57.	Menon GK, Elias PM and Feingold KR: Integrity of the permeability barrier is crucial for maintenance of the epidermal calcium gradient. Br J Dermatol. 130:139–147. 1994. View Article : Google Scholar : PubMed/NCBI
58.	Lee SH, Choi EH, Feingold KR, Jiang S and Ahn SK: Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol. 111:39–43. 1998. View Article : Google Scholar
59.	Menon GK, Price LF, Bommannan B, Elias PM and Feingold KR: Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J Invest Dermatol. 102:789–795. 1994. View Article : Google Scholar
60.	Holleran WM, Uchida Y, Halkier-Sorensen L, et al: Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function. Photodermatol Photoimmunol Photomed. 13:117–128. 1997. View Article : Google Scholar : PubMed/NCBI
61.	Hennings H, Michael D, Cheng C, Steinert P, Holbrook K and Yuspa SH: Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell. 19:245–254. 1980. View Article : Google Scholar
62.	Taylor SC: Skin of color: biology, structure, function, and implications for dermatologic disease. J Am Acad Dermatol. 46(Suppl): S41–S62. 2002. View Article : Google Scholar : PubMed/NCBI
63.	Pathak MA, Nghiem P and Fitzpatrick TB: Acute and chronic efects of the sun. Fitzpatrick’s Dermatology in General Medicine. Freedberg IM, Eisen AZ, Wolff K, Austen LA, Goldsmith K, Katz SI and Fitzpatrick TB: 1. 5th edition. McGraw-Hill; New York: pp. 1598–1607. 1999
64.	Rigel EG, Lebwohl M, Rigel AC and Rigel DS: Daily UVB exposure levels in high-school students measured with digital dosimeters. J Am Acad Dermatol. 49:1112–1114. 2003. View Article : Google Scholar : PubMed/NCBI
65.	Leenutaphong V, Nimkulrat P and Sudtim S: Comparison of phototherapy two times and four times a week with low doses of narrow-band ultraviolet B in Asian patients with psoriasis. Photodermatol Photoimmunol Photomed. 16:202–206. 2000. View Article : Google Scholar : PubMed/NCBI
66.	Murphy M, Mabruk MJ, Lenane P, et al: Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation. J Clin Pathol. 55:829–833. 2002. View Article : Google Scholar : PubMed/NCBI
67.	Narbutt J, Norval M, Slowik-Rylska M, et al: Suberythemal ultraviolet B radiation alters the expression of cell cycle-related proteins in the epidermis of human subjects without leading to photoprotection. Br J Dermatol. 161:890–896. 2009. View Article : Google Scholar
68.	Hong SP, Kim MJ, Jung MY, et al: Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. J Invest Dermatol. 128:2880–2887. 2008. View Article : Google Scholar : PubMed/NCBI
69.	Farrell AM, Uchida Y, Nagiec MM, et al: UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J Lipid Res. 39:2031–2038. 1998.