Application of adenosine stress echocardiography in the prognosis of acute myocardial infarction following percutaneous
coronary interventional therapy

Ren,Lihui; Liu,Yong; Lin,Jing; Ye,Huiming; Wang,Ping; Liu,Yingping

doi:10.3892/etm.2013.1193

September 2013 Volume 6 Issue 3

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September 2013 Volume 6 Issue 3

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Article

Application of adenosine stress echocardiography in the prognosis of acute myocardial infarction following percutaneous coronary interventional therapy

Authors:
- Lihui Ren
- Yong Liu
- Jing Lin
- Huiming Ye
- Ping Wang
- Yingping Liu
View Affiliations / Copyright

Affiliations: Department of Cardiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing 100038, P.R. China
Pages: 727-730
|
Published online on: July 1, 2013

https://doi.org/10.3892/etm.2013.1193
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Abstract

The aim of this study was to investigate the application of adenosine stress echocardiography (ASE) in the prognosis of acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI). A total of 79 patients with AMI who underwent PCI were selected for the study. ASE testing was performed within one week following the PCI. Subsequent to the ASE, the patients with ≥5% increases in the left ventricular ejection fraction (LVEF) levels were included in the improved LVEF group, while patients with <5% increases in LVEF levels were included in the unimproved LVEF group. A follow‑up study was performed during the 24 months subsequent to the ASE. The incidence of major adverse cardiovascular events (MACEs) was observed and compared between the two groups and logistic regression analysis was applied to identify the risk factors for clinical prognosis. There were no significant differences in Killip classification, LVEF, left ventricular end‑diastolic diameter or blood plasma B‑type natriuretic peptide concentration between the two groups following PCI. The incidence of MACEs in the improved LVEF group was significantly lower than that in unimproved LVEF group (14.29 versus 43.24%, respectively; P<0.05). Logistic regression analysis identified LVEF increases of <5% and segment improvements of ≤3 as the risk factors for the clinical prognosis of AMI following treatment with PCI. Therefore, ASE is an effective method of assessing the clinical effect of PCI treatment, which may be utilized to predict the incidence of MACEs following PCI.

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1	Huang X, Zhang L, Yuan Y, et al: Emergency interventional therapy of acute myocardial infarction and revascularization time relationship. Southern Medical University Science Bulletin. 27:119–120. 2007.(In Chinese).
2	Masci PG, Ganame J, Francone M, et al: Relationship between location and size of myocardial infarction and their reciprocal influences on post-infarction left ventricular remodelling. Eur Heart J. 32:1640–1648. 2011. View Article : Google Scholar : PubMed/NCBI
3	Marfella R, Di Filippo C, Portoghese M, et al: Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients. J Am Coll Cardiol. 53:1425–1436. 2009. View Article : Google Scholar : PubMed/NCBI
4	Simoni J, Simoni G, Wesson DE and Feola M: ATP-adenosine-glutathione cross-linked hemoglobin as clinically useful oxygen carrier. Curr Drug Discov Technol. 9:173–187. 2012. View Article : Google Scholar : PubMed/NCBI
5	Zhao YL and Ao HS: Research progress of myocardial ischemia-reperfusion injury. Chinese Circulation J. 26:396–398. 2011.(In Chinese).
6	Ma D, Yao H, Liu H, et al: Clinical value of adenosine ^99mTc-MIBI myocardial perfusion single photon emission computed tomography in percutaneous coronary intervention. Chinese Circulation J. 25:259–262. 2010.
7	Liu Y, Li Z, Yang Y and Wang Y: Assessment of myocardial viability in patients with myocardial infarction using strain rate imaging combined with low dose adenosine stress echocardiography. Chinese Journal of Ultrasound in Medicine. 24:236–239. 2008.
8	Sanchis J, Bodí V, Insa LD, et al: Predictors of early and late ventricular remodeling after acute myocardial infarction. Clin Cardiol. 22:581–586. 1999. View Article : Google Scholar : PubMed/NCBI
9	Lamas GA, Flaker GC, Mitchell G, et al; The Survival and Ventricular Enlargement Investigators. Effect of infarct artery patency on prognosis after acute myocardial infarction. Circulation. 92:1101–1109. 1995. View Article : Google Scholar : PubMed/NCBI
10	Jeremy RW, Hackworthy RA, Bautovich G, et al: Infarct artery perfusion and changes in left ventricular volume in the month after acute myocardial infarction. J Am Coll Cardiol. 9:989–995. 1987.PubMed/NCBI
11	Sharpe N, Smith H, Murphy J, et al: Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition. Lancet. 337:872–876. 1991. View Article : Google Scholar : PubMed/NCBI
12	Touchstone DA, Beller GA, Nygaard TW, et al: Effects of successful intravenous reperfusion therapy on regional myocardial function and geometry in humans: a tomographic assessment using two-dimensional echocardiography. J Am Coll Cardiol. 13:1506–1513. 1989. View Article : Google Scholar
13	Ito H, Maruyama A, Iwakura K, et al: Clinical implications of the ‘no reflow’ phenomenon. A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation. 93:223–228. 1996.
14	Pfeffer MA, Braunwald E, Moyé LA, et al; The SAVE Investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. N Engl J Med. 327:669–677. 1992. View Article : Google Scholar
15	Nixdorff U, Erbel R, Rupprecht HJ, et al: Sum of ST-segment elevations on admission electrocardiograms in acute myocardial infarction predicts left ventricular dilation. Am J Cardiol. 77:1237–1241. 1996. View Article : Google Scholar : PubMed/NCBI
16	Bosimini E, Giannuzzi P, Temporelli PL, et al: Electrocardiographic evolutionary changes and left ventricular remodeling after acute myocardial infarction: results of the GISSI-3 Echo substudy. J Am Coll Cardiol. 35:127–135. 2000. View Article : Google Scholar
17	Wu KC, Zerhouni EA, Judd RM, et al: Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 97:765–772. 1998. View Article : Google Scholar : PubMed/NCBI
18	Galiuto L, Garramone B, Scarà A, et al; AMICI Investigators. The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of post-infarct reperfusion in predicting left ventricular remodeling: results of the multicenter AMICI study. J Am Coll Cardiol. 51:552–559. 2008. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Application of adenosine stress echocardiography in the prognosis of acute myocardial infarction following percutaneous coronary interventional therapy

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