Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression

  • Authors:
    • Yu Wang
    • Yu Feng
    • Qunying Fu
    • Lei Li
  • View Affiliations

  • Published online on: July 11, 2013     https://doi.org/10.3892/etm.2013.1215
  • Pages: 826-830
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder and the main cause of dementia. Panax notoginsenoside Rb1 (PNRb1), which is also known as (3β,12β)-20‑[(6-O-β-D-glucopyranosyl-β‑D‑glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D‑glucopyranosyl‑β‑D‑glucopyranoside and is the main active component of the plant Panax notoginseng, is effective in treating AD. However, the mechanisms of PNRb1 remain unknown. In the present study, rat brain tissue sections were pretreated with PNRb1 and then induced by okadaic acid to establish brain slice models of AD. The results of qPCR and immunoblot analyses demonstrated that PNRb1 suppressed the protein expression of phosphorylated Tau and upregulated the expression levels of brain‑derived neurotrophic factor (BDNF). These results suggest that PNRb1 is able to upregulate the protein level of BDNF and downregulate Tau protein phosphorylation in AD.
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September 2013
Volume 6 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang Y, Feng Y, Fu Q and Li L: Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression. Exp Ther Med 6: 826-830, 2013
APA
Wang, Y., Feng, Y., Fu, Q., & Li, L. (2013). Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression. Experimental and Therapeutic Medicine, 6, 826-830. https://doi.org/10.3892/etm.2013.1215
MLA
Wang, Y., Feng, Y., Fu, Q., Li, L."Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression". Experimental and Therapeutic Medicine 6.3 (2013): 826-830.
Chicago
Wang, Y., Feng, Y., Fu, Q., Li, L."Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression". Experimental and Therapeutic Medicine 6, no. 3 (2013): 826-830. https://doi.org/10.3892/etm.2013.1215