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Article

Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion

  • Authors:
    • Yan Yang
    • Sujun Gao
    • Hongqiong Fan
    • Hai Lin
    • Wei Li
    • Juan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Haematology and Oncology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Oncology, People's Hospital of Jilin Province, Changchun, Jilin 130021, P.R. China
  • Pages: 803-807
    |
    Published online on: July 11, 2013
       https://doi.org/10.3892/etm.2013.1218
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Abstract

The aim of this study was to evaluate the efficacy and adverse effects of lenalidomide in the treatment of intermediate‑1 risk non‑5q deletion [non‑del (5q)] myelodysplastic syndrome (MDS). A total of 30 patients with MDS were classified through G‑banding chromosome karyotype analysis and fluorescence in situ hybridization (FISH). According to the International Prognostic Scoring System scores, among the 30 patients, 23 and seven cases had scores of 0.5 and 1.0, respectively. Lenalidomide (Revlimid®), 10 mg/day) was administered for 21 days every 28 days. All 30 cases were treated with lenalidomide for at least three cycles, including 20 cases with four cycles. The patients did not require erythropoietin, cyclosporine or iron chelation treatments. Statistical analysis was performed using SPSS statistical software version 13.0, and comparisons among groups were conducted using a t‑test. The efficacy of lenalidomide was demonstrated in patients with intermediate‑1 risk non‑del (5q) MDS. Peripheral blood cell counts were improved following treatment, and absolute neutrophil, haemoglobin and platelet counts increased following 2‑4 cycles of treatment. All patients became stable having undergone three cycles of treatment; however, 17 patients with chromosomal abnormalities had no cytogenetic response to the treatment, as confirmed through the FISH test. Patients with intermediate‑1 risk non‑del (5q) MDS treated with lenalidomide did not achieve complete haematological remission, although they demonstrated haematological improvement.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Gao S, Fan H, Lin H, Li W and Wang J: Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion. Exp Ther Med 6: 803-807, 2013.
APA
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., & Wang, J. (2013). Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion. Experimental and Therapeutic Medicine, 6, 803-807. https://doi.org/10.3892/etm.2013.1218
MLA
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., Wang, J."Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion". Experimental and Therapeutic Medicine 6.3 (2013): 803-807.
Chicago
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., Wang, J."Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion". Experimental and Therapeutic Medicine 6, no. 3 (2013): 803-807. https://doi.org/10.3892/etm.2013.1218
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Gao S, Fan H, Lin H, Li W and Wang J: Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion. Exp Ther Med 6: 803-807, 2013.
APA
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., & Wang, J. (2013). Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion. Experimental and Therapeutic Medicine, 6, 803-807. https://doi.org/10.3892/etm.2013.1218
MLA
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., Wang, J."Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion". Experimental and Therapeutic Medicine 6.3 (2013): 803-807.
Chicago
Yang, Y., Gao, S., Fan, H., Lin, H., Li, W., Wang, J."Analysis of the efficacy of lenalidomide in patients with intermediate‑1 risk myelodysplastic syndrome without 5q deletion". Experimental and Therapeutic Medicine 6, no. 3 (2013): 803-807. https://doi.org/10.3892/etm.2013.1218
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