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Article

Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action

  • Authors:
    • Rong Li
    • Guangrong Dai
    • Mengyun Zhao
    • Yonghong  Zhang
    • Li Hui
    • Xueli Zhang
    • Bin Jin
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Hospital of Xi'an City, Xi'an, Shaanxi 710002, P.R. China, Department of Gastroenterology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000, P.R. China
  • Pages: 904-908
    |
    Published online on: July 23, 2013
       https://doi.org/10.3892/etm.2013.1232
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Abstract

The aim of this study was to investigate the preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. A total of 60 rats were randomly divided into normal control, model control, high‑dose treatment and low-dose treatment groups, and a hepatic fibrosis model was established. The high- and low‑dose treatment groups were treated with 2 g/100 g and 0.5 g/100 g Astragalus flavescens, respectively, once a day. Eight weeks following the initiation of treatment, the liver specimens of the rats were stained and observed under a light microscope. Hepatic fibrosis indices, specifically, type III precollagen (PC III), type IV collagen (C IV), hyaluronic acid (HA) and laminin (LN), were detected. Furthermore, the expression and localization of the hepatic fibrosis‑related factors transforming growth factor‑β1 (TGF‑β1), connective tissue growth factor (CTGF) and platelet‑derived growth factor‑BB (PDGF‑BB) were determined. The serum levels of hepatic fibrosis indices, and the liver tissue levels of hepatic fibrosis‑related factors and collagen surface density in the model control group and the high- and low-dose treatment groups were significantly higher compared with those of the normal control group (P<0.05). In addition, the values in the two treatment groups were significantly lower compared with those of the model control group (P<0.05). The present study demonstrated that Astragalus flavescens effectively prevents hepatic fibrosis in rats. A possible mechanism for this is that it may reduce the expression levels of TGF‑β1, PDGF‑BB and CTGF, thereby inhibiting the activation of hepatic stellate cells and specifically blocking the signal transduction pathway of hepatic fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Li R, Dai G, Zhao M, Zhang Y, Hui L, Zhang X and Jin B: Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. Exp Ther Med 6: 904-908, 2013.
APA
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., & Jin, B. (2013). Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. Experimental and Therapeutic Medicine, 6, 904-908. https://doi.org/10.3892/etm.2013.1232
MLA
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., Jin, B."Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action". Experimental and Therapeutic Medicine 6.4 (2013): 904-908.
Chicago
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., Jin, B."Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action". Experimental and Therapeutic Medicine 6, no. 4 (2013): 904-908. https://doi.org/10.3892/etm.2013.1232
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Dai G, Zhao M, Zhang Y, Hui L, Zhang X and Jin B: Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. Exp Ther Med 6: 904-908, 2013.
APA
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., & Jin, B. (2013). Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action. Experimental and Therapeutic Medicine, 6, 904-908. https://doi.org/10.3892/etm.2013.1232
MLA
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., Jin, B."Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action". Experimental and Therapeutic Medicine 6.4 (2013): 904-908.
Chicago
Li, R., Dai, G., Zhao, M., Zhang, Y., Hui, L., Zhang, X., Jin, B."Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action". Experimental and Therapeutic Medicine 6, no. 4 (2013): 904-908. https://doi.org/10.3892/etm.2013.1232
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