Cervical spondylotic myelopathy with vitamin B12 deficiency: Two case reports

Xu,Yao; Chen,Wenjun; Jiang,Jianyuan

doi:10.3892/etm.2013.1240

October 2013 Volume 6 Issue 4

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October 2013 Volume 6 Issue 4

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Case Report

Cervical spondylotic myelopathy with vitamin B12 deficiency: Two case reports

Authors:
- Yao Xu
- Wenjun Chen
- Jianyuan Jiang
View Affiliations / Copyright

Affiliations: Department of Orthopedics, Huashan Affiliated Hospital of Fudan University, Jing'an, Shanghai 200040, P.R. China
Pages: 943-946
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Published online on: July 30, 2013

https://doi.org/10.3892/etm.2013.1240
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Abstract

Although it has been observed that a vitamin B12 (VB12) deficiency may lead to defects in the nervous system, there is a lack of studies elucidating whether VB12 has a role in the pathogenesis of cervical spondylotic myelopathy (CSM). The present study describes two cases of CSM observed in the clinic, where the patients presented with common characteristics of the typical clinical symptoms; however, T2-weighted magnetic resonance imaging examinations revealed that although the degree of spinal cord compression was not serious, the spinal cord exhibited significant high signal changes. At the same time, the serum VB12 levels of the two patients were lower compared with those of normal controls. The symptoms of the patients improved following anterior cervical decompression surgery and VB12 replacement therapy. The incidence of CSM in the two patients may have been correlated with a lack of VB12. Therefore, it is recommended that the serum VB12 levels are checked in cases of CSM where the standard imaging and clinical manifestations do not fully match.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cervical spondylotic myelopathy with vitamin B12 deficiency: Two case reports

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