Effects of cytokine‑induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery

Liu,Hongxiang; Song,Junmin; Yang,Zhen; Zhang,Xiefu

doi:10.3892/etm.2013.1247

October 2013 Volume 6 Issue 4

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October 2013 Volume 6 Issue 4

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Article

Effects of cytokine‑induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery

Authors:
- Hongxiang Liu
- Junmin Song
- Zhen Yang
- Xiefu Zhang
View Affiliations / Copyright

Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450012, P.R. China, Department of Anorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450012, P.R. China
Pages: 953-956
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Published online on: August 5, 2013

https://doi.org/10.3892/etm.2013.1247
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Abstract

The aim of this study was to investigate the effects of cytokine‑induced killer (CIK) cell treatment combined with FOLFOX4 on the recurrence and survival rates of patients suffering from gastric cancer following surgery. A total of 98 patients with gastric cancer, who were surgically treated from June 2010 to June 2012, were divided into two groups: 47 patients, who underwent FOLFOX4 treatment alone, served as the control group, while the remaining 51 patients received FOLFOX4 in combination with CIK cell immunotherapy and served as the observation group. The immune functions, recurrence and survival rates were estimated and compared between the two groups. No significant differences were observed between the immune functions of the patients prior to treatment compared with the functions following treatment (P>0.05). However, the immune functions of the patients were improved following FOLFOX4 treatment in combination with CIK cell immunotherapy compared with the functions of the patients who received FOLFOX4 treatment alone (P<0.05). The gastric cancer recurrence rates of the patients in the observation group were significantly lower compared with those of the patients in the control group (5.9 versus 25.5, 17.6 versus 36.2 and 23.5 versus 48.9% after 1, 2 and 3 years, respectively; P<0.05). In addition, the survival rates of the patients with gastric cancer in the observation group were significantly enhanced compared with those of the control group, as assessed by log‑rank test analysis (98.0 versus 93.6, 92.2 versus 78.7 and 72.5 versus 59.6% after 1, 2 and 3 years, respectively; P<0.05). It may be concluded that FOLFOX4 combined with CIK cell treatment has significant benefits for patients suffering from gastric cancer, compared with FOLFOX4 treatment alone.

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1.	Dong S, Li FQ, Zhang Q, Lv KZ, Yang HL, Gao Y and Yu JR: Expression and clinical significance of SHP2 in gastric cancer. J Int Med Res. 40:2083–2089. 2012. View Article : Google Scholar : PubMed/NCBI
2.	Martella B, Cardin F, Lorenzetti R, Terranova C, Amato B and Militello C: Local recurrence of gastric cancer after total gastrectomy: an unusual presentation. BMC Surg. 12(Suppl 1): S282012. View Article : Google Scholar : PubMed/NCBI
3.	Shi SB, Ma TH, Li CH and Tang XY: Effect of maintenance therapy with dendritic cells: cytokine-induced killer cells in patients with advanced non-small cell lung cancer. Tumori. 98:314–319. 2012.PubMed/NCBI
4.	Yang XJ, Huang JA, Lei W, Zhu YB and Zhang XG: Antitumor effects of cocultured dendritic cells and cytokine-induced killer cells on lung cancer in vitro and in vivo. Ai Zheng. 25:1329–1333. 2006.(In Chinese).
5.	Ma Y, Xu YC, Tang L, Zhang Z, Wang J and Wang HX: Cytokine-induced killer (CIK) cell therapy for patients with hepatocellular carcinoma: efficacy and safety. Exp Hematol Oncol. 1:112012. View Article : Google Scholar : PubMed/NCBI
6.	Basili G, Nesi G, Barchielli A, Manetti A and Biliotti G: Pathologic features and long-term results in early gastric cancer: report of 116 cases 8–13 years after surgery. World J Surg. 27:149–152. 2003.PubMed/NCBI
7.	Marrelli D, Roviello F, De Stefano A, Fotia G, Giliberto C, Garosi L and Pinto E: Risk factors for liver metastases after curative surgical procedures for gastric cancer: a prospective study of 208 patients treated with surgical resection. J Am Coll Surg. 198:51–58. 2004.
8.	Zhou QM, Wu PH, Zhao M, et al: Short-term curative efficacy of cytokine-induced killer cells combined micro-invasive treatments on hepatocellular carcinoma. Ai Zheng. 25:1414–1418. 2006.(In Chinese).
9.	Blattman JN and Greenberg PD: Cancer immunotherapy: a treatment for the masses. Science. 305:200–205. 2004. View Article : Google Scholar : PubMed/NCBI
10.	Shi L, Zhou Q, Wu J, Ji M, Li G, Jiang J and Wu C: Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother. 61:2251–2259. 2012. View Article : Google Scholar : PubMed/NCBI
11.	Rutella S and Locatelli F: Is there a role for cytokine-induced killer cells in cancer immunotherapy? Immunotherapy. 4:867–869. 2012. View Article : Google Scholar : PubMed/NCBI
12.	Sangiolo D: Cytokine induced killer cells as promising immuno-therapy for solid tumors. J Cancer. 2:363–368. 2011. View Article : Google Scholar : PubMed/NCBI
13.	Jäkel CE, Hauser S, Rogenhofer S, Müller SC, Brossart P and Schmidt-Wolf IG: Clinical studies applying cytokine-induced killer cells for the treatment of renal cell carcinoma. Clin Dev Immunol. 2012:4732452012.PubMed/NCBI
14.	Sangiolo D, Mesiano G, Carnevale-Schianca F, Piacibello W, Aglietta M and Cignetti A: Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin Biol Ther. 9:831–840. 2009. View Article : Google Scholar
15.	Zhang J, Zhu L, Wei J, Liu L, Yin Y, Gu Y and Shu Y: The effects of cytokine-induced killer cells for the treatment of patients with solid tumors: a clinical retrospective study. J Cancer Res Clin Oncol. 138:1057–1062. 2012. View Article : Google Scholar : PubMed/NCBI
16.	Schlimper C, Hombach AA, Abken H and Schmidt-Wolf IG: Improved activation toward primary colorectal cancer cells by antigen-specific targeting autologous cytokine-induced killer cells. Clin Dev Immunol. 2012:2389242012. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of cytokine‑induced killer cell treatment combined with FOLFOX4 on the recurrence and survival rates for gastric cancer following surgery

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