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Article

Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029

  • Authors:
    • Hyeong-U Son
    • Sang-Han Lee
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of Korea
  • Pages: 909-912
    |
    Published online on: August 5, 2013
       https://doi.org/10.3892/etm.2013.1249
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Abstract

The aim of this study was to investigate whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester produced by cell subtype Beauveria bassiana CS1029 causes acute toxicity when used for cosmetic purposes by performing an eye irritation test. New Zealand white (NZW) rabbits were treated with a 100 mg/dose of S-(-)-10,11‑dihydroxyfarnesic acid methyl ester according to standard procedure guidelines. No significant changes in terms of ocular lesions of the cornea, turbidity of the cornea, swelling of the eyelid or ocular discharge were observed in the methyl ester‑treated groups, while sodium dioctyl sulfosuccinate, a positive control, caused severe toxicity. The anatomical and pathological observations indicate that the methyl ester produced by Beauveria bassiana CS1029 did not induce eye irritation in the lenses of the rabbits. The data suggest that the methyl ester evaluated in this study has promising potential as a cosmetic ingredient that does not irritate the eye.
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Copy and paste a formatted citation
Spandidos Publications style
Son H and Lee S: Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029. Exp Ther Med 6: 909-912, 2013.
APA
Son, H., & Lee, S. (2013). Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029. Experimental and Therapeutic Medicine, 6, 909-912. https://doi.org/10.3892/etm.2013.1249
MLA
Son, H., Lee, S."Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029". Experimental and Therapeutic Medicine 6.4 (2013): 909-912.
Chicago
Son, H., Lee, S."Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029". Experimental and Therapeutic Medicine 6, no. 4 (2013): 909-912. https://doi.org/10.3892/etm.2013.1249
Copy and paste a formatted citation
x
Spandidos Publications style
Son H and Lee S: Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029. Exp Ther Med 6: 909-912, 2013.
APA
Son, H., & Lee, S. (2013). Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029. Experimental and Therapeutic Medicine, 6, 909-912. https://doi.org/10.3892/etm.2013.1249
MLA
Son, H., Lee, S."Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029". Experimental and Therapeutic Medicine 6.4 (2013): 909-912.
Chicago
Son, H., Lee, S."Evaluation of eye irritation by S-(-)-10,11-dihydroxyfarnesic acid methyl ester secreted by Beauveria bassiana CS1029". Experimental and Therapeutic Medicine 6, no. 4 (2013): 909-912. https://doi.org/10.3892/etm.2013.1249
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