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Article

Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats

  • Authors:
    • Batur Niyaz
    • Kai-Liang Zhao
    • Li-Min Liu
    • Chen Chen
    • Wen‑Hong Deng
    • Teng Zuo
    • Qiao Shi
    • Wei-Xing Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of General Surgery, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China
  • Pages: 989-994
    |
    Published online on: August 7, 2013
       https://doi.org/10.3892/etm.2013.1255
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Abstract

Peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti‑inflammatory effects. However, the mechanisms by which PPAR‑γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR‑γ ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate‑induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high‑lipid diet‑induced hyperlipidemia and SAP.
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Copy and paste a formatted citation
Spandidos Publications style
Niyaz B, Zhao K, Liu L, Chen C, Deng WH, Zuo T, Shi Q and Wang W: Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Exp Ther Med 6: 989-994, 2013.
APA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T. ... Wang, W. (2013). Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Experimental and Therapeutic Medicine, 6, 989-994. https://doi.org/10.3892/etm.2013.1255
MLA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6.4 (2013): 989-994.
Chicago
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6, no. 4 (2013): 989-994. https://doi.org/10.3892/etm.2013.1255
Copy and paste a formatted citation
x
Spandidos Publications style
Niyaz B, Zhao K, Liu L, Chen C, Deng WH, Zuo T, Shi Q and Wang W: Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Exp Ther Med 6: 989-994, 2013.
APA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T. ... Wang, W. (2013). Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Experimental and Therapeutic Medicine, 6, 989-994. https://doi.org/10.3892/etm.2013.1255
MLA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6.4 (2013): 989-994.
Chicago
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6, no. 4 (2013): 989-994. https://doi.org/10.3892/etm.2013.1255
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