Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats

  • Authors:
    • Batur Niyaz
    • Kai-Liang Zhao
    • Li-Min Liu
    • Chen Chen
    • Wen‑Hong Deng
    • Teng Zuo
    • Qiao Shi
    • Wei-Xing Wang
  • View Affiliations

  • Published online on: August 7, 2013     https://doi.org/10.3892/etm.2013.1255
  • Pages: 989-994
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Peroxisome proliferator‑activated receptor‑γ (PPAR‑γ) ligand regulates adipocyte differentiation and insulin sensitivity, and exerts antihyperlipidemic and anti‑inflammatory effects. However, the mechanisms by which PPAR‑γ ligands affect hyperlipidemia with severe acute pancreatitis (SAP) have not been fully elucidated. The present study investigated the effects of rosiglitazone, a PPAR‑γ ligand, on hyperlipidemia with SAP in a rat model. The hyperlipidemia was induced with a high-fat diet and SAP was induced by the administration of sodium taurocholate (TCA). The hyperlipidemia was shown to aggravate the severity of the sodium taurocholate‑induced SAP. However, rosiglitazone demonstrated significant antihyperlipidemic and anti-inflammatory effects in the rats with high‑lipid diet‑induced hyperlipidemia and SAP.
View Figures
View References

Related Articles

Journal Cover

October 2013
Volume 6 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Niyaz B, Zhao K, Liu L, Chen C, Deng WH, Zuo T, Shi Q and Wang W: Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Exp Ther Med 6: 989-994, 2013
APA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T. ... Wang, W. (2013). Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats. Experimental and Therapeutic Medicine, 6, 989-994. https://doi.org/10.3892/etm.2013.1255
MLA
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6.4 (2013): 989-994.
Chicago
Niyaz, B., Zhao, K., Liu, L., Chen, C., Deng, W., Zuo, T., Shi, Q., Wang, W."Rosiglitazone attenuates the severity of hyperlipidemic severe acute pancreatitis in rats". Experimental and Therapeutic Medicine 6, no. 4 (2013): 989-994. https://doi.org/10.3892/etm.2013.1255