Behavioral and biochemical effects of a formulation of the traditional Chinese medicine, Kai‑Xin‑San, in fatigued rats

Hu,Yuan; Cao ,Yin; Liu,Ming; Liu,Ping; Cui,Hong; Dai‑Hong,Guo

doi:10.3892/etm.2013.1256

October 2013 Volume 6 Issue 4

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October 2013 Volume 6 Issue 4

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Article

Behavioral and biochemical effects of a formulation of the traditional Chinese medicine, Kai‑Xin‑San, in fatigued rats

Authors:
- Yuan Hu
- Yin Cao
- Ming Liu
- Ping Liu
- Hong Cui
- Guo Dai‑Hong
View Affiliations / Copyright

Affiliations: Department of Clinical Pharmacology, Pharmacy Care Center, Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Psychology, Chinese PLA General Hospital, Beijing 100853, P.R. China
Pages: 973-976
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Published online on: August 7, 2013

https://doi.org/10.3892/etm.2013.1256
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Abstract

The present study was designed to evaluate the anti‑fatigue activity and the behavioral and biochemical effects of Kai‑Xin‑San (KXS) extracts on fatigued rats. The rats were randomly divided into six groups: untreated control (UC), running control (RC), RC treated with 13 mg/kg/day modafinil and RC treated with KXS at dosages of 125, 250 and 500 mg/kg/day, respectively. The treatments were administered orally. Anti‑fatigue activity was assessed using the treadmill running test and serum biochemical parameters were determined using an autoanalyzer and commercially available kits. Furthermore, the standardization of the KXS extracts was ensured using a high‑performance liquid chromatography (HPLC)‑fingerprint. The extracts were shown to increase exhaustive running time in the treadmill running test and reverse the fatigue‑induced reduction in hepatic/muscle glycogen and testosterone, in addition to reducing the lactate dehydrogenase (LDH), serum urea nitrogen (SUN), blood lactic acid (BLA) and β‑endorphin levels in the serum of the fatigued rats. Moreover, the extracts enhanced superoxide dismutase (SOD) activity and decreased the malondialdehyde (MDA) levels in the serum of the fatigued rats. The results of this preliminary study indicated that KXS exhibits anti‑fatigue activity. This was reflected in the effects on the biochemical markers for fatigue.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Behavioral and biochemical effects of a formulation of the traditional Chinese medicine, Kai‑Xin‑San, in fatigued rats

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