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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Inhibition of SENP1 induces radiosensitization in lung cancer cells

  • Authors:
    • Ruo‑Tian Wang
    • Xiu‑Yi Zhi
    • Yi Zhang
    • Jian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Xuanwu Hospital of Capital Medical University (CMU), Beijing 100053, P.R. China
  • Pages: 1054-1058
    |
    Published online on: August 8, 2013
       https://doi.org/10.3892/etm.2013.1259
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Abstract

Lung cancer is one of the most common and lethal types of malignancy. To date, radiotherapy and chemotherapy have been used as the two major treatment methods. However, radioresistance of lung cancer remains a therapeutic hindrance. The aim of this study was to identify whether small ubiquitin‑related modifier (SUMO)-specific protease 1 (SENP1) is a marker of radioresistance that may serve as a target for enhancing the efficacy of lung carcinoma radiotherapy. SENP1 was observed to be overexpressed in lung cancer tissues, and the modulation of SENP1 expression was demonstrated to significantly affect the proliferation of lung cancer cells. Moreover, silencing the expression of SENP1 using small interfering RNA (siRNA) significantly sensitized lung cancer cells to radiation. Mechanically, it was demonstrated that SENP1 depletion significantly enhanced ionizing radiation (IR)‑induced cell cycle arrest, γ‑H2AX expression and apoptosis. Thus, these data suggest that SENP1 may be a desirable drug target for lung carcinoma radiotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Wang RT, Zhi XY, Zhang Y and Zhang J: Inhibition of SENP1 induces radiosensitization in lung cancer cells. Exp Ther Med 6: 1054-1058, 2013.
APA
Wang, R., Zhi, X., Zhang, Y., & Zhang, J. (2013). Inhibition of SENP1 induces radiosensitization in lung cancer cells. Experimental and Therapeutic Medicine, 6, 1054-1058. https://doi.org/10.3892/etm.2013.1259
MLA
Wang, R., Zhi, X., Zhang, Y., Zhang, J."Inhibition of SENP1 induces radiosensitization in lung cancer cells". Experimental and Therapeutic Medicine 6.4 (2013): 1054-1058.
Chicago
Wang, R., Zhi, X., Zhang, Y., Zhang, J."Inhibition of SENP1 induces radiosensitization in lung cancer cells". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1054-1058. https://doi.org/10.3892/etm.2013.1259
Copy and paste a formatted citation
x
Spandidos Publications style
Wang RT, Zhi XY, Zhang Y and Zhang J: Inhibition of SENP1 induces radiosensitization in lung cancer cells. Exp Ther Med 6: 1054-1058, 2013.
APA
Wang, R., Zhi, X., Zhang, Y., & Zhang, J. (2013). Inhibition of SENP1 induces radiosensitization in lung cancer cells. Experimental and Therapeutic Medicine, 6, 1054-1058. https://doi.org/10.3892/etm.2013.1259
MLA
Wang, R., Zhi, X., Zhang, Y., Zhang, J."Inhibition of SENP1 induces radiosensitization in lung cancer cells". Experimental and Therapeutic Medicine 6.4 (2013): 1054-1058.
Chicago
Wang, R., Zhi, X., Zhang, Y., Zhang, J."Inhibition of SENP1 induces radiosensitization in lung cancer cells". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1054-1058. https://doi.org/10.3892/etm.2013.1259
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