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Article

Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies

  • Authors:
    • Chenyun Zhang
    • Wei Yi
    • Yunchang Cai
    • Shounian Fang
    • Xinan Jiang
    • Anzhi Wen
    • Qiang Wu
  • View Affiliations / Copyright

    Affiliations: Guizhou Provincial Cardiovascular Institute and Cardiology Department of Guizhou Provincial Hospital, Guiyang, Guizhou 550002, P.R. China
  • Pages: 1044-1048
    |
    Published online on: August 16, 2013
       https://doi.org/10.3892/etm.2013.1262
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Abstract

The aim of this study was to investigate the safety and effectiveness of a novel method for the selective transcoronary closure of small coronary arteries by the intraluminal application of radiofrequency (RF) energy. Twenty-six small (diameter of 1-2 mm) coronary artery branches were selected in 13 dogs. An RF electrode wire (CRW-Zcy) was placed into the target vessel and a coronary balloon was used to transiently block the blood flow and limit damage to the proximal vessel. A therapeutic dosage of 20-30 W of RT energy every 10-30 sec (selected according the diameter of the target artery) was discharged via the CRW-Zcy inside a microcatheter two or three times in order to achieve arterial closure. A high dosage of 60 W every 120 sec of RF energy was used to conduct the safety study. All 26 branches were successfully closed resulting in the complete blockage of the antegrade and retrograde flows. The area of injury was limited to the target artery and the supplied myocardium. High-dose RF did not cause injury to the adjacent vessels and myocardium. The animals tolerated the procedure well without any untoward systemic effects. A follow-up angiography at two weeks revealed no evidence of recanalization or retrograde filling of the target artery. Percutaneous transluminal radiofrequency closure is a safe and effective interventional approach for closing the small coronary arteries, and is potentially valuable for further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Yi W, Cai Y, Fang S, Jiang X, Wen A and Wu Q: Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies. Exp Ther Med 6: 1044-1048, 2013.
APA
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., & Wu, Q. (2013). Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies. Experimental and Therapeutic Medicine, 6, 1044-1048. https://doi.org/10.3892/etm.2013.1262
MLA
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., Wu, Q."Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies". Experimental and Therapeutic Medicine 6.4 (2013): 1044-1048.
Chicago
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., Wu, Q."Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1044-1048. https://doi.org/10.3892/etm.2013.1262
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Yi W, Cai Y, Fang S, Jiang X, Wen A and Wu Q: Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies. Exp Ther Med 6: 1044-1048, 2013.
APA
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., & Wu, Q. (2013). Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies. Experimental and Therapeutic Medicine, 6, 1044-1048. https://doi.org/10.3892/etm.2013.1262
MLA
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., Wu, Q."Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies". Experimental and Therapeutic Medicine 6.4 (2013): 1044-1048.
Chicago
Zhang, C., Yi, W., Cai, Y., Fang, S., Jiang, X., Wen, A., Wu, Q."Percutaneous transluminal radiofrequency closure of the coronary artery in animal studies". Experimental and Therapeutic Medicine 6, no. 4 (2013): 1044-1048. https://doi.org/10.3892/etm.2013.1262
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