Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice

  • Authors:
    • Yu Qian
    • Xin Zhao
    • Jia-Le Song
    • Kai Zhu
    • Peng Sun
    • Gui-Jie Li
    • Rui Wang
    • Jian-Quan Kan
  • View Affiliations / Copyright

    Affiliations: College of Food Science, Southwest University, Chongqing 400715, P.R. China, Department of Biological and Chemical Engineering, Chongqing University of Education, Na'an, Chongqing 400067, P.R. China, Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Republic of Korea
  • Pages: 1312-1316
    |
    Published online on: September 2, 2013
       https://doi.org/10.3892/etm.2013.1280
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to determine the effects of resistant starch 3 (RS3) as a carrier for stachyose on dextran sulfate sodium (DSS)‑induced colitis in C57BL/6 mice. RS3 microspheres carrying stachyose (RS3 + stachyose) were produced and evaluated as a potentially improved colitis therapy for this study. The body weights of the mice treated with RS3 + stachyose were higher compared with those of DSS-treated control mice. RS3 + stachyose reduced the levels of the serum pro-inflammatory cytokines IL-6 and TNF-α to a greater extent compared with the same concentration of stachyose combined with ordinary starch (stachyose + starch). Histopathological examination of sections of colon tissues showed that the RS3 + stachyose group recovered well from colitis; however, the tissue sections of the stachyose + starch group presented necrosis to a more serious degree. These results suggest that stachyose with an RS3 carrier has better preventative effects on colitis than stachyose alone in mice.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1. 

No authors listed:. Report of a Joint FAO/WHO Expert Consultation: Carbohydrates in human nutrition. FAO Food Nutr Pap. 66:1–140. 1998.

2. 

Englyst HN, Kingman SM and Cummings JH: Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr. 46(Suppl 2): S33–S50. 1992.PubMed/NCBI

3. 

Baghurst PA, Baghurst KI and Record SJ: Dietary fiber, non-starch polysaccharides and resistant starch - a review. Food Australia. 48(Suppl): S1–S36. 1996.

4. 

Yin J, Yang G, Wang S and Chen Y: Purification and determination of stachyose in Chinese artichoke (Stachys Sieboldii Miq.) by high-performance liquid chromatography with evaporative light scattering detection. Talanta. 70:208–212. 2006.PubMed/NCBI

5. 

Liying Z, Li D, Qiao S, Johnson EW, Li B, Thacker PA and Han IK: Effects of stachyose on performance, diarrhoea incidence and intestinal bacteria in weanling pigs. Arch Tierernahr. 57:1–10. 2003.PubMed/NCBI

6. 

Macfarlane GT and Cummings JH: Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? West J Med. 171:187–191. 1999.

7. 

Xu Q, Chao YL and Wan QB: Health benefit application of functional oligosaccharides. Carbohydrate Polymers. 77:435–441. 2009. View Article : Google Scholar

8. 

Jian R, Besterman HS, Sarson DL, et al: Colonic inhibition of gastric secretion in man. Dig Dis Sci. 26:195–201. 1981. View Article : Google Scholar : PubMed/NCBI

9. 

Seo GS and Choi SC: Pathophysiology of ulcerative colitis - relationship with genetics and immunity. Korea J Med. 76:643–648. 2009.(In Korean).

10. 

Stange EF, Travis SP, Vermeire S, Beglinger C, Kupcinkas L, Geboes K, et al European Crohn’s and Colitis Organisation: European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Gut. 55(Suppl 1): 1–15. 2006.

11. 

Ramadori G and Armbrust T: Cytokines in the liver. Eur J Gastroenterol Hepatol. 13:777–784. 2001. View Article : Google Scholar : PubMed/NCBI

12. 

McCurry KR, Campbell DA Jr, Scales WE, Warren JS and Remick DG: Tumor necrosis factor, interleukin 6, and the acute phase response following hepatic ischemia/reperfusion. J Surg Res. 55:49–54. 1993. View Article : Google Scholar : PubMed/NCBI

13. 

Ming WJ, Bersani L and Mantovani A: Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J Immunol. 138:1469–1472. 1987.PubMed/NCBI

14. 

Fayyaz M and Lackner JM: Serotonin receptor modulators in the treatment of irritable bowel syndrome. Ther Clin Risk Manag. 4:41–48. 2008.PubMed/NCBI

15. 

Melgar S, Karlsson L, Rehnström E, Karlsson A, Utkovic H, Jansson L and Michaëlsson E: Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease. Int immunopharmacol. 8:836–844. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Ogawa A, Andoh A, Araki Y, Bamba T and Fujiyama Y: Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol. 110:55–62. 2004. View Article : Google Scholar : PubMed/NCBI

17. 

Soriano A, Salas A, Salas A, Sans M, Gironella M, Elena M, Anderson DC, Piqué JM and Panés J: VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab Invest. 80:1541–1551. 2000. View Article : Google Scholar : PubMed/NCBI

18. 

Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB and Ruddle FH: Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15–p21. Genomics. 2:203–208. 1988.PubMed/NCBI

19. 

van der Poll T, Keogh CV, Guirao X, Buurman WA, Kopf M and Lowry SF: Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis. 176:439–444. 1997.PubMed/NCBI

20. 

Gosselin D and Rivest S: Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr Hyde duality of the innate immune system. Brain Behav Immun. 21:281–289. 2007.PubMed/NCBI

21. 

Wan GS, Zhao ZZ, Qian YL, Xie ZH, Wang ZH and Zhu JJ: Changes in serum levels of SOCS-3, IL-6 and TNF-α and their correlation in patients with ulcerative colitis. World Chinese J Digestol. 19:3370–3373. 2011.(In Chinese).

22. 

Barondeau DP, Kassmann CJ, Bruns CK, Tainer JA and Getzoff ED: Nickel superoxide dismutase structure and mechanism. Biochemistry. 43:8038–8047. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Gaze DC: The role of existing and novel cardiac biomarkers for cardioprotection. Curr Opin Investig Drugs. 8:711–717. 2007.PubMed/NCBI

24. 

Alscher RG, Erturk N and Heath LS: Role of superoxide dismutases (SODs) in controlling oxidative stress in plants. J Exp Bot. 53:1331–1341. 2002. View Article : Google Scholar : PubMed/NCBI

25. 

Topping DL and Clifton PM: Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 81:1031–1064. 2001.PubMed/NCBI

26. 

Berggren AM, Bjorck IM, Nyman EM and Eggum BO: Short-chain fatty acid content and pH in caecum of rats given various sources of carbohydrates. J Sci Food Agri. 63:397–406. 1993.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qian Y, Zhao X, Song J, Zhu K, Sun P, Li G, Wang R and Kan J: Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice. Exp Ther Med 6: 1312-1316, 2013.
APA
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G. ... Kan, J. (2013). Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice. Experimental and Therapeutic Medicine, 6, 1312-1316. https://doi.org/10.3892/etm.2013.1280
MLA
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G., Wang, R., Kan, J."Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice". Experimental and Therapeutic Medicine 6.5 (2013): 1312-1316.
Chicago
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G., Wang, R., Kan, J."Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1312-1316. https://doi.org/10.3892/etm.2013.1280
Copy and paste a formatted citation
x
Spandidos Publications style
Qian Y, Zhao X, Song J, Zhu K, Sun P, Li G, Wang R and Kan J: Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice. Exp Ther Med 6: 1312-1316, 2013.
APA
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G. ... Kan, J. (2013). Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice. Experimental and Therapeutic Medicine, 6, 1312-1316. https://doi.org/10.3892/etm.2013.1280
MLA
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G., Wang, R., Kan, J."Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice". Experimental and Therapeutic Medicine 6.5 (2013): 1312-1316.
Chicago
Qian, Y., Zhao, X., Song, J., Zhu, K., Sun, P., Li, G., Wang, R., Kan, J."Inhibitory effects of resistant starch (RS3) as a carrier for stachyose on dextran sulfate sodium‑induced ulcerative colitis in C57BL/6 mice". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1312-1316. https://doi.org/10.3892/etm.2013.1280
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team