Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells

  • Authors:
    • Quanliang Liu
    • Xinghuan Wang
  • View Affiliations

  • Published online on: September 13, 2013     https://doi.org/10.3892/etm.2013.1301
  • Pages: 1277-1282
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Abstract

Transient receptor potential vanilloid 2 (TRPV2), a nonselective cation channel, has become an attractive target gene for tumor studies due to its wide range of physiological and pathological functions. However, its specific role in bladder cancer development and progression remains unclear. The aim of the present study was to investigate the effects of TRPV2 on the proliferation, migration and invasion of 5637 bladder cancer cells in vitro. Rat TRPV2 cDNA was transfected into 5637 bladder cancer cells and changes in the behavior of the cells were detected. It was observed that TRPV2 enhanced bladder cancer cell migration and invasion; however, it did not affect cell proliferation in vitro. TRPV2 activity, which may be mediated by direct matrix metalloproteinase 2 (MMP2) regulation, is important in bladder tumor development and progression. The results of this study suggest that TRPV2 channels are a potential therapeutic target for bladder carcinoma.
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November 2013
Volume 6 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Q and Liu Q: Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells. Exp Ther Med 6: 1277-1282, 2013
APA
Liu, Q., & Liu, Q. (2013). Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells. Experimental and Therapeutic Medicine, 6, 1277-1282. https://doi.org/10.3892/etm.2013.1301
MLA
Liu, Q., Wang, X."Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells". Experimental and Therapeutic Medicine 6.5 (2013): 1277-1282.
Chicago
Liu, Q., Wang, X."Effect of TRPV2 cation channels on the proliferation, migration and invasion of 5637 bladder cancer cells". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1277-1282. https://doi.org/10.3892/etm.2013.1301