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Article

Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris

  • Authors:
    • Yun-Hui Li
    • Xi Huang
    • Yang Wang
    • Rong Fan
    • Hong-Min Zhang
    • Ping Ren
    • Yao Chen
    • Hong-Hao Zhou
    • Zhao-Qian Liu
    • Yi-Zeng Liang
    • Hong-Mei Lu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Ethnopharmacology, Department of Integrated Chinese and Western Medicine, The National Key Clinical Specialist Vocational School, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Laboratory of Ethnopharmacology, Department of Integrated Chinese and Western Medicine, The National Key Clinical Specialist Vocational School, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Henan Eye Institute and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China, TCM Pharmacogenetics Laboratory, Central South University, Changsha, Hunan 410008, P.R. China, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P.R. China
  • Pages: 1283-1289
    |
    Published online on: September 17, 2013
       https://doi.org/10.3892/etm.2013.1302
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Abstract

Coronary heart disease (CHD) is the leading cause of mortality worldwide. The Chinese medicinal formula Guanxin II has been shown to have a favorable effect in the attenuation of angina. The aim of this study was to compare the pharmacokinetics of ferulic acid (FA), which is a vasorelaxant compound present in Guanxin II, in healthy volunteers and patients with angina pectoris following the administration of Guanxin II. Ex vivo experiments were performed in order to investigate the vasorelaxant effect of FA on the human internal mammary artery (IMA) to provide evidence that it is a bioactive component of Guanxin II. Following the oral administration of Guanxin II, the FA levels in the serum were quantified by a simple and rapid high-performance liquid chromatography (HPLC) method. Treatment with FA (10-8-10-3 M) caused a concentration‑dependent relaxation of endothelial IMA rings following precontraction with KCl. Statistically significant differences were identified between the pharmacokinetic parameters Cmax, t1/2α, t1/2β and t1/2Ka of the healthy volunteers and the patients with angina pectoris following the oral administration of Guanxin II. FA is a bioactive compound absorbed from Guanxin II that attenuates angina pectoris, a condition that may modify the pharmacokinetics of FA. Not only do the pharmacokinetic parameters direct the clinical use of Guanxin II, but they may also be useful for exploring the pathology of angina pectoris.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Huang X, Wang Y, Fan R, Zhang H, Ren P, Chen Y, Zhou H, Liu Z, Liang Y, Liang Y, et al: Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris. Exp Ther Med 6: 1283-1289, 2013.
APA
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P. ... Lu, H. (2013). Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris. Experimental and Therapeutic Medicine, 6, 1283-1289. https://doi.org/10.3892/etm.2013.1302
MLA
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P., Chen, Y., Zhou, H., Liu, Z., Liang, Y., Lu, H."Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris". Experimental and Therapeutic Medicine 6.5 (2013): 1283-1289.
Chicago
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P., Chen, Y., Zhou, H., Liu, Z., Liang, Y., Lu, H."Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1283-1289. https://doi.org/10.3892/etm.2013.1302
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Huang X, Wang Y, Fan R, Zhang H, Ren P, Chen Y, Zhou H, Liu Z, Liang Y, Liang Y, et al: Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris. Exp Ther Med 6: 1283-1289, 2013.
APA
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P. ... Lu, H. (2013). Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris. Experimental and Therapeutic Medicine, 6, 1283-1289. https://doi.org/10.3892/etm.2013.1302
MLA
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P., Chen, Y., Zhou, H., Liu, Z., Liang, Y., Lu, H."Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris". Experimental and Therapeutic Medicine 6.5 (2013): 1283-1289.
Chicago
Li, Y., Huang, X., Wang, Y., Fan, R., Zhang, H., Ren, P., Chen, Y., Zhou, H., Liu, Z., Liang, Y., Lu, H."Pharmacokinetic comparison of the vasorelaxant compound ferulic acid following the administration of Guanxin II to healthy volunteers and patients with angina pectoris". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1283-1289. https://doi.org/10.3892/etm.2013.1302
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