Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of propofol on renal ischemia/reperfusion injury in rats

  • Authors:
    • Shun Yang
    • Wei-Ping Chou
    • Ling Pei
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, First University Hospital of China Medical University, Shenyang, Liaoning 110000, P.R. China, Department of Anesthesiology, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China
  • Pages: 1177-1183
    |
    Published online on: September 18, 2013
       https://doi.org/10.3892/etm.2013.1305
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Renal ischemia/reperfusion injury (IRI) is a major cause of acute renal failure. The aim of this study was to investigate whether propofol pretreatment in a rat model protects kidney tissue against IRI. Thirty-two Wistar rats were equally divided into four groups: a sham-operated group, untreated renal IRI group, and low-dose (5 mg/kg) and high-dose (10 mg/kg) propofol-treated groups which were treated with propofol prior to the induction of IRI. The rats were subjected to renal ischemia by bilateral clamping of the pedicles for 50 min, followed by reperfusion. The low-dose and high-dose propofol treatment groups were pretreated via femoral vein injection with a propofol suspension prior to the induction of ischemia/reperfusion. The untreated IRI group showed significantly higher serum creatinine (SCr), blood urea nitrogen (BUN), interleukin 6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and malondialdehyde (MDA) levels compared with the sham‑operated rats. Superoxide dismutase (SOD) levels were significantly reduced following IRI; however, they significantly increased following propofol administration. Bone morphogenetic protein 2 (BMP2) levels were significantly increased in the propofol-treated groups compared with the untreated IRI group. These results suggest that propofol reduces renal oxidative injury and facilitates repair following IRI. Propofol may play a protective role by regulating BMP2 expression in renal IRI.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1. 

Bonventre JV and Zuk A: Ischemic acute renal failure: an inflammatory disease? Kidney Int. 66:480–485. 2004. View Article : Google Scholar : PubMed/NCBI

2. 

Thurman JM: Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol. 123:7–13. 2007. View Article : Google Scholar : PubMed/NCBI

3. 

Ysebaert DK, De Greef KE, De Beuf A, et al: T cells as mediators in renal ischemia/reperfusion injury. Kidney Int. 66:491–496. 2004. View Article : Google Scholar : PubMed/NCBI

4. 

Erdogan H, Fadillioglu E, Yagmurca M, Ucar M and Irmak MK: Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: protective effects of erdosteine and N-acetylcysteine. Urol Res. 34:41–46. 2006. View Article : Google Scholar

5. 

Li XL, Zou XM, Gao P, Li YL, Wang H and Chen XW: Role of nitric oxide in ischemia-reperfusion injury and acute rejection in rat intestinal transplantation. Transplant Proc. 40:3342–3345. 2008. View Article : Google Scholar : PubMed/NCBI

6. 

Xia Z, Godin DV, Chang TK and Ansley DM: Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F2t-isoprostane formation. Can J Physiol Pharmacol. 81:14–21. 2003. View Article : Google Scholar : PubMed/NCBI

7. 

Javadov SA, Lim KH, Kerr PM, Suleiman MS, Angelini GD and Halestrap AP: Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition. Cardiovasc Res. 45:360–369. 2000. View Article : Google Scholar : PubMed/NCBI

8. 

Kokita N, Hara A, Abiko Y, Arakawa J, Hashizume H and Namiki A: Propofol improves functional and metabolic recovery in ischemic reperfused isolated rat hearts. Anesth Analg. 86:252–258. 1998.PubMed/NCBI

9. 

Yang CY, Wong CS, Yu CC, Luk HN and Lin CI: Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology. 84:626–635. 1996. View Article : Google Scholar : PubMed/NCBI

10. 

Zhou W, Fontenot HJ, Liu S and Kennedy RH: Modulation of cardiac calcium channels by propofol. Anesthesiology. 86:670–675. 1997. View Article : Google Scholar : PubMed/NCBI

11. 

Jordan JE, Zhao ZQ and Vinten-Johansen J: The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res. 43:860–878. 1999. View Article : Google Scholar : PubMed/NCBI

12. 

Simpson PJ, Fantone JC, Mickelson JK, Gallagher KP and Lucchesi BR: Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion. Circ Res. 63:1070–1079. 1988. View Article : Google Scholar

13. 

Shin IW, Lim BW, Chung YS, et al: The effect of propofol on myocardial protection after regional ischemia-reperfusion injury in an in vivo rat heart model. Korean J Anesthesiol. 55:338–343. 2008. View Article : Google Scholar

14. 

Nauth A, Ristiniemi J, McKee MD and Schemitsch EH: Bone morphogenetic proteins in open fractures: past, present, and future. Injury. 40(Suppl 3): S27–S31. 2009. View Article : Google Scholar : PubMed/NCBI

15. 

El-Bizri N, Guignabert C, Wang L, et al: SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development. 135:2981–2991. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Hansmann G, de Jesus Perez VA, Alastalo TP, et al: An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest. 118:1846–1857. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Wybenga DR, Di Giorgio J and Pileggi VJ: Manual and automated methods for urea nitrogen measurement in whole serum. Clin Chem. 17:891–895. 1971.PubMed/NCBI

18. 

Kueltzo LA, Ersoy B, Ralston JP and Middaugh CR: Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: a bGCSF case study. J Pharm Sci. 92:1805–1820. 2003. View Article : Google Scholar

19. 

Paller MS, Hoidal JR and Ferris TF: Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest. 74:1156–1164. 1984. View Article : Google Scholar : PubMed/NCBI

20. 

Morsy MD, Mostafa OA and Hassan WN: A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats. J Biomed Sci. 17:552010. View Article : Google Scholar : PubMed/NCBI

21. 

Sasaki M and Joh T: Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents. J Clin Biochem Nutr. 40:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

22. 

van der Heijden M, Versteilen AM, Sipkema P, van Nieuw Amerongen GP, Musters RJ and Groeneveld AB: Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis. 13:404–412. 2008.

23. 

Bayrak O, Turgut F, Karatas OF, et al: Oral beta-glucan protects kidney against ischemia/reperfusion injury in rats. Am J Nephrol. 28:190–196. 2008. View Article : Google Scholar : PubMed/NCBI

24. 

Schramm L, Weierich T, Heldbreder E, Zimmermann J, Netzer KO and Wanner C: Endotoxin-induced acute renal failure in rats: effects of L-arginine and nitric oxide synthase inhibition on renal function. J Nephrol. 18:374–381. 2005.PubMed/NCBI

25. 

Spek CA, Brüggemann LW and Borensztajn KS: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. Shock. 33:339author reply 339–340. 2010. View Article : Google Scholar

26. 

Petronijević ND, Mićić DV, Duricić B, Marinković D and Paunović VR: Substrate kinetics of erythrocyte membrane Na, K-ATPase and lipid peroxides in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 27:431–440. 2003.PubMed/NCBI

27. 

Kato R and Foëx P: Myocardial protection by anesthetic agents against ischemia-reperfusion injury: an update for anesthesiologists. Can J Anaesth. 49:777–791. 2002. View Article : Google Scholar : PubMed/NCBI

28. 

Jin YC, Kim W, Ha YM, et al: Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo. Vascul Pharmacol. 50:71–77. 2009. View Article : Google Scholar : PubMed/NCBI

29. 

Sánchez-Conde P, Rodriguez-López JM, Nicolás JL, et al: The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping. Anesth Analg. 106:371–378. 2008.PubMed/NCBI

30. 

Yuzbasioglu MF, Aykas A, Kurutas EB and Sahinkanat T: Protective effects of propofol against ischemia/reperfusion injury in rat kidneys. Ren Fail. 32:578–583. 2010. View Article : Google Scholar : PubMed/NCBI

31. 

Yuzer H, Yuzbasioglu MF, Ciralik H, et al: Effects of intravenous anesthetics on renal ischemia/reperfusion injury. Ren Fail. 31:290–296. 2009. View Article : Google Scholar : PubMed/NCBI

32. 

Dhore CR, Cleutjens JP, Lutgens E, et al: Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 21:1998–2003. 2001. View Article : Google Scholar : PubMed/NCBI

33. 

Sorescu GP, Song H, Tressel SL, et al: Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 95:773–779. 2004. View Article : Google Scholar

34. 

Shin V, Zebboudj AF and Boström K: Endothelial cells modulate osteogenesis in calcifying vascular cells. J Vasc Res. 41:193–201. 2004. View Article : Google Scholar

35. 

Sorescu GP, Sykes M, Weiss D, et al: Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem. 278:31128–31135. 2003. View Article : Google Scholar : PubMed/NCBI

36. 

Abe J: Bone morphogenetic protein (BMP) family, SMAD signaling and Id helix-loop-helix proteins in the vasculature: the continuous mystery of BMPs pleiotropic effects. J Mol Cell Cardiol. 41:4–7. 2006. View Article : Google Scholar

37. 

Csiszar A, Lehoux S and Ungvari Z: Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. Antioxid Redox Signal. 11:1683–1697. 2009. View Article : Google Scholar : PubMed/NCBI

38. 

Ten Dijke P, Goumans MJ, Itoh F and Itoh S: Regulation of cell proliferation by Smad proteins. J Cell Physiol. 191:1–16. 2002.PubMed/NCBI

39. 

Funaki C, Hodges RR and Dartt DA: Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. Am J Physiol Cell Physiol. 293:C1551–C1560. 2007. View Article : Google Scholar : PubMed/NCBI

40. 

Csiszar A, Ahmad M, Smith KE, et al: Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol. 168:629–638. 2006. View Article : Google Scholar : PubMed/NCBI

41. 

Csiszar A, Smith KE, Koller A, Kaley G, Edwards JG and Ungvari Z: Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation. 111:2364–2372. 2005. View Article : Google Scholar

42. 

Yang YL, Ju HZ, Liu SF, et al: BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition. J Cell Biochem. 112:2558–2565. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang S, Chou W and Pei L: Effects of propofol on renal ischemia/reperfusion injury in rats. Exp Ther Med 6: 1177-1183, 2013.
APA
Yang, S., Chou, W., & Pei, L. (2013). Effects of propofol on renal ischemia/reperfusion injury in rats. Experimental and Therapeutic Medicine, 6, 1177-1183. https://doi.org/10.3892/etm.2013.1305
MLA
Yang, S., Chou, W., Pei, L."Effects of propofol on renal ischemia/reperfusion injury in rats". Experimental and Therapeutic Medicine 6.5 (2013): 1177-1183.
Chicago
Yang, S., Chou, W., Pei, L."Effects of propofol on renal ischemia/reperfusion injury in rats". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1177-1183. https://doi.org/10.3892/etm.2013.1305
Copy and paste a formatted citation
x
Spandidos Publications style
Yang S, Chou W and Pei L: Effects of propofol on renal ischemia/reperfusion injury in rats. Exp Ther Med 6: 1177-1183, 2013.
APA
Yang, S., Chou, W., & Pei, L. (2013). Effects of propofol on renal ischemia/reperfusion injury in rats. Experimental and Therapeutic Medicine, 6, 1177-1183. https://doi.org/10.3892/etm.2013.1305
MLA
Yang, S., Chou, W., Pei, L."Effects of propofol on renal ischemia/reperfusion injury in rats". Experimental and Therapeutic Medicine 6.5 (2013): 1177-1183.
Chicago
Yang, S., Chou, W., Pei, L."Effects of propofol on renal ischemia/reperfusion injury in rats". Experimental and Therapeutic Medicine 6, no. 5 (2013): 1177-1183. https://doi.org/10.3892/etm.2013.1305
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team