Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy

Wang,Xiang-Chuan; Liu,Chun-Hui; Chen,Yun-Jing; Wu,Yang; Yang,Lei-Shan; Liu,Hong-Min; Liao,Hai-Li

doi:10.3892/etm.2013.1306

November 2013 Volume 6 Issue 5

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November 2013 Volume 6 Issue 5

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Article

Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy

Authors:
- Xiang-Chuan Wang
- Chun-Hui Liu
- Yun-Jing Chen
- Yang Wu
- Lei-Shan Yang
- Hong-Min Liu
- Hai-Li Liao
View Affiliations / Copyright

Affiliations: Department of Nephrology, No. 163 Hospital of PLA, Changsha, Hunan 410003, P.R. China
Pages: 1243-1246
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Published online on: September 18, 2013

https://doi.org/10.3892/etm.2013.1306
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Abstract

The aim of the present study was to identify the association between pathological types of kidney and clinical manifestations in patients with hypertensive nephropathy. The blood pressure, fundus, urinalysis test results and renal function changes were analysed in patients who were treated for hypertensive nephropathy. Downward kidney puncture biopsy was performed using a 16G ejection needle with the aid of B ultrasound in 47 cases. The specimens were observed using light microscopy and immunofluorescence. The pathological changes observed in the patients exhibiting symptoms of hypertensive nephropathy varied. The majority of clinical manifestations were benign arteriolar nephrosclerosis, hyaline degeneration of the renal artery and the appearance of a thickened wall of a thickened renal artery wall. Severe cases showed malignant arteriolar nephrosclerosis characterised by fibrinoid necrosis of renal arterioles and intimal hyperplasia. In addition, in the severe cases, fibrinoid necrosis of the afferent arteriole and arcuate artery wall was observed, with severe interlobular artery and arcuate artery myointimal thickening. Renal biopsy in patients with hypertensive nephropathy is safe and feasible. The prognosis and treatment of pathological and clinical disease related to renal pathology is necessary.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy

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