Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores

  • Authors:
    • Quan Zhang
    • Ye Zhang
    • Wenjun Chen
    • Bingwen Zhang
    • Shilong Wang
  • View Affiliations

  • Published online on: September 30, 2013     https://doi.org/10.3892/etm.2013.1323
  • Pages: 1443-1448
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Abstract

The aim of this study was to investigate the ability of mesoporous bioactive glass with ordered nanopores (80S MBG) to adsorb and provide the delayed release of 125I-tagged bone morphogenetic protein-2 (BMP-2). A 50 mg piece of 80S MBG was produced, which comprised SiO2, CaO and P2O5 in a component molar ratio of 80:15:5. Each MBG piece adsorbed 30 µg 125I-BMP-2. Persistent radioactivity in the MBG was periodically measured in simulated body fluid. The total amount of BMP‑2 released and the mean amount released per day were calculated. A delayed release curve of BMP-2 was constructed. SPSS 15.0 software was used to perform a statistical analysis. The amount of BMP-2 released in the first two days was one-quarter of the total load. A line equation, y = 490.55x1/2 + 7268.82, was obtained from the square root of protein release doses value at 3-94 days. The total amount of BMP-2 released over 94 days was 11.894 µg, which was ~39.6% of the total load. The half-life of the release time was 248 days. From the second week, the rate of BMP release had stabilized to a mean of 37.42±18.67 ng/day and the difference of the mean amount released per day had no statistical significance (P>0.05). High adsorption and delayed release effects of BMP-2 were observed in 80S MBG. The delayed release conforms to the Higuchi equation, which indicates possible applications in promoting bone healing.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Q, Zhang Y, Chen W, Zhang B and Wang S: Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores. Exp Ther Med 6: 1443-1448, 2013
APA
Zhang, Q., Zhang, Y., Chen, W., Zhang, B., & Wang, S. (2013). Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores. Experimental and Therapeutic Medicine, 6, 1443-1448. https://doi.org/10.3892/etm.2013.1323
MLA
Zhang, Q., Zhang, Y., Chen, W., Zhang, B., Wang, S."Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores". Experimental and Therapeutic Medicine 6.6 (2013): 1443-1448.
Chicago
Zhang, Q., Zhang, Y., Chen, W., Zhang, B., Wang, S."Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1443-1448. https://doi.org/10.3892/etm.2013.1323