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Article

Lentinus edodes promotes fat removal in hypercholesterolemic mice

  • Authors:
    • Hyun Yang
    • Inho Hwang
    • Sun Kim
    • Eui‑Ju Hong
    • Eui‑Bae Jeung
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361‑763, Republic of Korea
  • Pages: 1409-1413
    |
    Published online on: October 8, 2013
       https://doi.org/10.3892/etm.2013.1333
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Abstract

Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phospholipid metabolism. In the present study, the effects of L. edodes in a mouse model of hypercholesterolemia were investigated. Hypercholesterolemia was induced by the consumption of a high‑fat diet (HFD). The animals were divided into six groups, which were fed a normal diet, HFD alone, HFD containing eritadenine [10 mg/kg of body weight (BW)] or HFD with 5, 10 or 20% L. edodes, respectively, for 4 weeks (from 5 to 9 weeks of age). The mice in the six groups had similar BW gains. Total serum cholesterol (T‑CHO), low‑density lipoprotein (LDL) and triglyceride (TG) levels were increased in the HFD‑fed group compared with those in the normal diet group. However, the levels of high‑density lipoprotein (HDL) were not significantly altered. In mice treated with L. edodes (5, 10 or 20%), the T‑CHO, LDL and TG serum levels were reduced in a dose‑dependent manner. The mRNA expression of cholesterol 7‑α‑hydroxylase 1 (CYP7A1) was decreased in hypercholesterolemic mice and increased by eritadenine and L. edodes (5, 10 and 20%) supplementation. In liver tissues, it was observed that lipid accumulation was reduced by treatment with eritadenine and L. edodes. In addition, it was revealed that the formation of atherosclerotic plaques due to the HFD was also suppressed by eritadenine and L. edodes. The results of the study indicated that the consumption of an HFD may inhibit CYP7A1 expression in the liver by increasing serum T‑CHO, LDL and TG levels. L. edodes may help regulate lipid metabolism, suggesting that this fungus ameliorates hypercholesterolemia in mice by regulating CYP7A1 expression in the liver.
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1 

Wasser SP: Shiitake (Lentinus edodes). Encyclopedia of Dietary Supplements. View Article : Google Scholar : Marcel Dekker; New York: pp. 653–664. 2005

2 

Ngai PH and Ng TB: Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci. 73:3363–3374. 2003. View Article : Google Scholar

3 

Shimada Y, Morita T and Sugiyama K: Eritadenine-induced alterations of plasma lipoprotein lipid concentrations and phosphatidylcholine molecular species profile in rats fed cholesterol-free and cholesterol-enriched diets. Biosci Biotechnol Biochem. 67:996–1006. 2003. View Article : Google Scholar

4 

Sugiyama K, Akachi T and Yamakawa A: Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats. J Nutr. 125:2134–2144. 1995.PubMed/NCBI

5 

Shimada Y, Morita T and Sugiyama K: Dietary eritadenine and ethanolamine depress fatty acid desaturase activities by increasing liver microsomal phosphatidylethanolamine in rats. J Nutr. 133:758–765. 2003.PubMed/NCBI

6 

Fukada S, Setoue M, Morita T and Sugiyama K: Dietary eritadenine suppresses guanidinoacetic acid-induced hyperhomocysteinemia in rats. J Nutr. 136:2797–2802. 2006.PubMed/NCBI

7 

Adachi R, Honma Y, Masuno H, et al: Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. J Lipid Res. 46:46–57. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Teo NH, Scott JM, Reed B, Neale G and Weir DG: Bile acid inhibition of vitamin B12 binding by intrinsic factor in vitro. Gut. 22:270–276. 1981. View Article : Google Scholar : PubMed/NCBI

9 

Seo YK, Chung YT, Kim S, Echchgadda I, Song CS and Chatterjee B: Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin. Gene. 386:218–223. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Russell DW and Setchell KD: Bile acid biosynthesis. Biochemistry. 31:4737–4749. 1992. View Article : Google Scholar

11 

Hubacek JA and Bobkova D: Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering. Mol Diagn Ther. 10:93–100. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Moon MS, Lee MS, Kim CT and Kim Y: Dietary chitosan enhances hepatic CYP7A1 activity and reduces plasma and liver cholesterol concentrations in diet-induced hypercholesterolemia in rats. Nutr Res Pract. 1:175–179. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Chawla A, Saez E and Evans RM: Don’t know much bile-ology. Cell. 103:1–4. 2000.

14 

Liu Y, Wu H, Wu W, Li R and Huang Y: Intervention of Huanglian Jiedu decoction on haemorheology and cholesterol-supplemented diet. Zhongguo Zhong Yao Za Zhi. 34:600–604. 2009.(In Chinese).

15 

Tuncer MA, Yaymaci B, Sati L, et al: Influence of Tribulus terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochem. 111:488–500. 2009.

16 

von Holt K, Lebrun S, Stinn W, Conroy L, Wallerath T and Schleef R: Progression of atherosclerosis in the Apo E−/− model: 12-month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet. Atherosclerosis. 205:135–143. 2009.

17 

Chibata I, Okumura K, Takeyama S and Kotera K: Lentinacin: a new hypocholesterolemic substance in Lentinus edodes. Experientia. 25:1237–1238. 1969. View Article : Google Scholar : PubMed/NCBI

18 

Kabir Y, Yamaguchi M and Kimura S: Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 33:341–346. 1987.

19 

Carbonero ER, Gracher AHP, Komura DL, et al: Lentinus edodes heterogalactan: Antinociceptive and anti-inflammatory effects. Food Chem. 111:531–537. 2008. View Article : Google Scholar

20 

Lee GS, Byun HS, Yoon KH, Lee JS, Choi KC and Jeung EB: Dietary calcium and vitamin D2 supplementation with enhanced Lentinula edodes improves osteoporosis-like symptoms and induces duodenal and renal active calcium transport gene expression in mice. Eur J Nutr. 48:75–83. 2009.PubMed/NCBI

21 

Takashima K, Sato C, Sasaki Y, Morita T and Takeyama S: Effect of eritadenine on cholesterol metabolism in the rat. Biochem Pharmacol. 23:433–438. 1974. View Article : Google Scholar : PubMed/NCBI

22 

Enman J, Rova U and Berglund KA: Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). J Agric Food Chem. 55:1177–1180. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Peet DJ, Turley SD, Ma W, et al: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 93:693–704. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Torchia EC, Cheema SK and Agellon LB: Coordinate regulation of bile acid biosynthetic and recovery pathways. Biochem Biophys Res Commun. 225:128–133. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Agellon LB, Drover VA, Cheema SK, Gbaguidi GF and Walsh A: Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem. 277:20131–20134. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Lambrinoudaki I, Kaparos G, Papadimitriou D, et al: Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women. Eur J Endocrinol. 159:233–241. 2008. View Article : Google Scholar

27 

Hofman MK, Princen HM, Zwinderman AH and Jukema JW: Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events. Clin Sci (Lond). 108:539–545. 2005. View Article : Google Scholar

28 

Yiu WF, Kwan PL, Wong CY, et al: Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase. J Food Sci. 76:H80–H89. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Hwang I, Kim S, Hong EJ and Jeung EB: Lentinus edodes promotes fat removal in hypercholesterolemic mice. Exp Ther Med 6: 1409-1413, 2013.
APA
Yang, H., Hwang, I., Kim, S., Hong, E., & Jeung, E. (2013). Lentinus edodes promotes fat removal in hypercholesterolemic mice. Experimental and Therapeutic Medicine, 6, 1409-1413. https://doi.org/10.3892/etm.2013.1333
MLA
Yang, H., Hwang, I., Kim, S., Hong, E., Jeung, E."Lentinus edodes promotes fat removal in hypercholesterolemic mice". Experimental and Therapeutic Medicine 6.6 (2013): 1409-1413.
Chicago
Yang, H., Hwang, I., Kim, S., Hong, E., Jeung, E."Lentinus edodes promotes fat removal in hypercholesterolemic mice". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1409-1413. https://doi.org/10.3892/etm.2013.1333
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Hwang I, Kim S, Hong EJ and Jeung EB: Lentinus edodes promotes fat removal in hypercholesterolemic mice. Exp Ther Med 6: 1409-1413, 2013.
APA
Yang, H., Hwang, I., Kim, S., Hong, E., & Jeung, E. (2013). Lentinus edodes promotes fat removal in hypercholesterolemic mice. Experimental and Therapeutic Medicine, 6, 1409-1413. https://doi.org/10.3892/etm.2013.1333
MLA
Yang, H., Hwang, I., Kim, S., Hong, E., Jeung, E."Lentinus edodes promotes fat removal in hypercholesterolemic mice". Experimental and Therapeutic Medicine 6.6 (2013): 1409-1413.
Chicago
Yang, H., Hwang, I., Kim, S., Hong, E., Jeung, E."Lentinus edodes promotes fat removal in hypercholesterolemic mice". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1409-1413. https://doi.org/10.3892/etm.2013.1333
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