Celecoxib effectively inhibits the formation of joint adhesions

Li,Fengfeng; He,Bin; Liu,Shen; Fan,Cunyi

doi:10.3892/etm.2013.1336

Celecoxib effectively inhibits the formation of joint adhesions

Authors:
- Fengfeng Li
- Bin He
- Shen Liu
- Cunyi Fan
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Affiliations: Department of Orthopedics, Sixth Affiliated People's Hospital of Shanghai Jiaotong University, Shanghai 200233, P.R. China, Department of Orthopedics, Second Affiliated Hospital of Nanjing Medical College, Nanjing 210011, P.R. China
Published online on: October 9, 2013 https://doi.org/10.3892/etm.2013.1336
Pages: 1507-1511

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Abstract

The present study investigated the effectiveness of celecoxib in preventing the formation of joint adhesions. Rabbit models of joint adhesion were created and the rabbits in two treatment groups were orally administered celecoxib or ibuprofen (as a positive control) for 30 days. Rabbits in the control group did not receive any treatment. Following the 30‑day experimental period, the inhibitory effects of celecoxib and ibuprofen on the formation of joint adhesion were assessed using a number of methods, including the study of macroscopic appearance, histology and contracture angle. Thick fibrous adhesions developed in the knees of the rabbits in the control group. By contrast, few adhesions were observed in the two treatment groups, and those observed were soft, weak and easily stretched. Fewer adhesions were observed in the rabbits treated with celecoxib than in the rabbits in the other groups. The adhesion scores and contracture angles in the celecoxib (P<0.001) and ibuprofen (0.001

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