Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December 2013 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2013 Volume 6 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model

  • Authors:
    • Rui Chen
    • Junyu Wang
    • Bing Jiang
    • Xin Wan
    • Hongwei Liu
    • Huan Liu
    • Xiaosheng Yang
    • Xiaobing Wu
    • Qin Zou
    • Wenren Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China, Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China, Department of Cardiology, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China, Department of Cardiology, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China, Department of Neurosurgery, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China, Department of Neurosurgery, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China
  • Pages: 1463-1468
    |
    Published online on: October 11, 2013
       https://doi.org/10.3892/etm.2013.1342
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of this study was to investigate the apoptosis of nerve cells in the hippocampal and thalamencephalon regions using a rabbit model of ventricular fluid impact. The results for the study demonstrated a variety of pathophysiological changes in the rabbit model, while changes in the hippocampal and thalamencephalon regions were observed under a light microscope following hematoxylin and eosin (H&E)/terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Among the mild, moderate and severe injury groups, there were significant differences in the mortality rate and in the changes in vital signs and consciousness recovery time following trauma. Furthermore, H&E staining showed that pathological changes, such as hemorrhage and necrosis, occurred in the hippocampal and thalamencephalon regions at an early stage subsequent to trauma, while TUNEL staining showed that neuronal apoptosis occurred in the various injury groups. In traumatic brain injuries, the impact caused by cerebrospinal fluid moving with a certain energy results in marked damage to the contralateral periventricular structures and may generate a series of pathophysiological changes.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Adelson PD, Fellows-Mayle W, Kochanek PM and Dixon CE: Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat. Childs Nerv Sys. 29:43–53. 2013. View Article : Google Scholar

2 

Mouzon BC, Chaytow H, Crynen G, et al: Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes. J Neurotrauma. 29:2761–2773. 2012. View Article : Google Scholar

3 

Li Y, Zhang L, Kallakuri S, Zhou R and Cavanaugh JM: Injury predictors for traumatic axonal injury in a rodent head impact acceleration model. Stapp Car Crash J. 55:25–47. 2011.PubMed/NCBI

4 

Feeney DM, Boyeson MG, Linn RT, Murray HM and Dail WG: Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res. 211:67–77. 1981. View Article : Google Scholar : PubMed/NCBI

5 

Dijkers MP, Harrison-Felix C and Marwitz JH: The traumatic brain injury model systems: history and contributions to clinical service and research. J Head Trauma Rehabil. 25:81–91. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Morganti-Kossmann MC, Yan E and Bye N: Animal models of traumatic brain injury: is there an optimal model to reproduce human brain injury in the laboratory? Injury. 41(Suppl 1): S10–S13. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM and Brody DL: Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study. Neurobiol Dis. 40:555–564. 2010.PubMed/NCBI

8 

Tashlykov V, Katz Y, Gazit V, Zohar O, Schreiber S and Pick CG: Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice. Brain Res. 1130:197–205. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Kockro RA, Giacomelli R, Scheihing M, Aschoff A and Hampl JA: A stereotactic device for rabbits based on mandibular and cranial landmarks: technical note. J Neurosurg. 108:601–606. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Marbacher S, Andereggen L, Neuschmelting V, et al: A new rabbit model for the study of early brain injury after subarachonoid hemorrhage. J Neurosci Methods. 208:138–145. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Khan M, Im YB, Shunmugavel A, Gilg AG, et al: Administration of S-nitrosoglutathione after tramatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 6:322009. View Article : Google Scholar : PubMed/NCBI

12 

Kao C, Forbes JA, Jermakowicz WJ, et al: Suppression of thalamocortical oscillations following traumatic brain injury in rats. J Neurosurg. 117:316–323. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Rostami E, Davidsson J, Ng KC, et al: A model for mild traumatic brain injury that induces limited transient memory impairment and increased levels of axon related serum biomarkers. Front Neurol. 3:1152012. View Article : Google Scholar : PubMed/NCBI

14 

Singleton RH, Yan HQ, Fellows-Mayle W and Dixon CE: Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury. J Neurotrauma. 27:1091–1099. 2010. View Article : Google Scholar

15 

Alessandri B, Nishioka T, Heimann A, Bullock RM and Kempski O: Caspase-dependent cell death involved in brain damage after acute subdural hematoma in rats. Brain Res. 1111:196–202. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Wei XE, Wang D, Li MH, Zhang YZ, Li YH and Li WB: A useful tool for the initial assessment of blood-brain barrier permeability after traumatic brain injury in rabbits: dynamic contrast-enhanced magnetic resonance imaging. J Trauma. 71:1645–1650. 2011. View Article : Google Scholar

17 

Xing G, Ren M, O’Neill JT, et al: Pyruvate dehydrogenase phosphatase1 mRNA expression is divergently and dynamically regulated between rat cerebral cortex, hippocampus and thalamus after traumatic brain injury: a potential biomarker of TBI-induced hyper- and hypo-glycaemia and neuronal vulnerability. Neurosci Lett. 525:140–145. 2012.

18 

Fearing MA, Bigler ED, Wilde EA, et al: Morphometric MRI findings in the thalamus and brainstem in children after moderate to severe traumatic brain injury. J Child Neurol. 23:729–737. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Scheibel RS, Newsome MR, Troyanskaya M, et al: Effects of severity of traumatic brain injury and brain reserve on cognitive-control related brain activation. J Neurotrauma. 26:1447–1461. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Monea AG, Verpoest I, Vander Sloten J, Van der Perre G, Goffin J and Depreitere B: Assessment of relative brain-skull motion in quasistatic circumstances by magnetic resonance imaging. J Neurotrauma. 29:2305–2317. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ragatsky GG, Kamenir Y and Mayevsky A: Effects of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury. Brain Res. 1047:131–136. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Rønning PA, Pedersen T, Skaga NO, Helseth E, Langmoen IA and Stavem K: External validation of a prognostic model for early mortality after traumatic brain injury. J Trauma. 70:E56–E61. 2011.PubMed/NCBI

23 

Schoeler M, Loetscher PD, Rossaint R, Fahlenkamp AV, et al: Dexmedetomidine is neuroprotive in an vitro model for traumatic brain injury. BMC Neurol. 12:202012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen R, Wang J, Jiang B, Wan X, Liu H, Liu H, Yang X, Wu X, Zou Q, Yang W, Yang W, et al: Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Exp Ther Med 6: 1463-1468, 2013.
APA
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H. ... Yang, W. (2013). Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Experimental and Therapeutic Medicine, 6, 1463-1468. https://doi.org/10.3892/etm.2013.1342
MLA
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H., Yang, X., Wu, X., Zou, Q., Yang, W."Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model". Experimental and Therapeutic Medicine 6.6 (2013): 1463-1468.
Chicago
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H., Yang, X., Wu, X., Zou, Q., Yang, W."Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1463-1468. https://doi.org/10.3892/etm.2013.1342
Copy and paste a formatted citation
x
Spandidos Publications style
Chen R, Wang J, Jiang B, Wan X, Liu H, Liu H, Yang X, Wu X, Zou Q, Yang W, Yang W, et al: Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Exp Ther Med 6: 1463-1468, 2013.
APA
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H. ... Yang, W. (2013). Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model. Experimental and Therapeutic Medicine, 6, 1463-1468. https://doi.org/10.3892/etm.2013.1342
MLA
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H., Yang, X., Wu, X., Zou, Q., Yang, W."Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model". Experimental and Therapeutic Medicine 6.6 (2013): 1463-1468.
Chicago
Chen, R., Wang, J., Jiang, B., Wan, X., Liu, H., Liu, H., Yang, X., Wu, X., Zou, Q., Yang, W."Study of cell apoptosis in the hippocampus and thalamencephalon in a ventricular fluid impact model". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1463-1468. https://doi.org/10.3892/etm.2013.1342
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team