Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate

  • Authors:
    • Bin Liu
    • Wen‑Yi Sun
    • Chen‑Yang Zhi
    • Tian‑Cheng Lu
    • Hai‑Mei Gao
    • Jian‑Hua Zhou
    • Wei‑Qun Yan
    • Hai‑Cheng Gao
  • View Affiliations

  • Published online on: October 14, 2013     https://doi.org/10.3892/etm.2013.1344
  • Pages: 1499-1503
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Abstract

Colorectal cancer (CRC) is a leading cause of cancer‑related mortality. The early diagnosis and treatment of CRC is the key to improving the survival of patients who may benefit from adjuvant chemotherapy. In the present study, the protein expression of S100A3 was observed in a cohort of 20 patients with cancer, which indicated that S100A3 activation was involved in tumorigenesis. In addition, the anticancer activity of cantharidinate was investigated using immunohistochemistry and quantitative polymerase chain reaction (qPCR) analysis. The protein expression of S100A3 was observed to increase by 2.4‑fold in human CRC cells compared with the expression level in normal control cells (P<0.01). Cantharidinate inhibited the protein and gene expression of S100A3 in UCT-116 human CRC cells in vitro. These results suggested that S100A3 is important in human CRC. Cantharidinate has the potential to be considered as a novel adjuvant drug for controlling the expression of S100A3 in human CRC as it exhibits preventive effects.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu B, Sun WY, Zhi CY, Lu TC, Gao HM, Zhou JH, Yan WQ and Gao HC: Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate. Exp Ther Med 6: 1499-1503, 2013
APA
Liu, B., Sun, W., Zhi, C., Lu, T., Gao, H., Zhou, J. ... Gao, H. (2013). Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate. Experimental and Therapeutic Medicine, 6, 1499-1503. https://doi.org/10.3892/etm.2013.1344
MLA
Liu, B., Sun, W., Zhi, C., Lu, T., Gao, H., Zhou, J., Yan, W., Gao, H."Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate". Experimental and Therapeutic Medicine 6.6 (2013): 1499-1503.
Chicago
Liu, B., Sun, W., Zhi, C., Lu, T., Gao, H., Zhou, J., Yan, W., Gao, H."Role of S100A3 in human colorectal cancer and the anticancer effect of cantharidinate". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1499-1503. https://doi.org/10.3892/etm.2013.1344