Protective effect of exogenous matrix metalloproteinase‑9 on chronic renal failure

  • Authors:
    • Lei Wang
    • Jue Wang
    • Yong Wang
    • Qiang Fu
    • Yong‑Hua Lei
    • Zhi‑Yong Nie
    • Jianxin Qiu
    • Ting‑Yi Bao
  • View Affiliations

  • Published online on: November 15, 2013     https://doi.org/10.3892/etm.2013.1409
  • Pages: 329-334
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Abstract

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP‑9 on CRF. An adenine‑induced model of CRF was generated in rabbits. Following the injection of MMP‑9 into the renal arteries of the rabbits, significant improvements in renal morphology and serum levels of creatinine and urea nitrogen were observed. Furthermore, MMP‑9 administration was shown to decrease the serum TIMP‑1 concentration and upregulate renal MMP‑9 expression. These results demonstrate a directly protective role for MMP‑9 in CRF.
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2014-February
Volume 7 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang L, Wang J, Wang Y, Fu Q, Lei YH, Nie ZY, Qiu J and Bao TY: Protective effect of exogenous matrix metalloproteinase‑9 on chronic renal failure. Exp Ther Med 7: 329-334, 2014
APA
Wang, L., Wang, J., Wang, Y., Fu, Q., Lei, Y., Nie, Z. ... Bao, T. (2014). Protective effect of exogenous matrix metalloproteinase‑9 on chronic renal failure. Experimental and Therapeutic Medicine, 7, 329-334. https://doi.org/10.3892/etm.2013.1409
MLA
Wang, L., Wang, J., Wang, Y., Fu, Q., Lei, Y., Nie, Z., Qiu, J., Bao, T."Protective effect of exogenous matrix metalloproteinase‑9 on chronic renal failure". Experimental and Therapeutic Medicine 7.2 (2014): 329-334.
Chicago
Wang, L., Wang, J., Wang, Y., Fu, Q., Lei, Y., Nie, Z., Qiu, J., Bao, T."Protective effect of exogenous matrix metalloproteinase‑9 on chronic renal failure". Experimental and Therapeutic Medicine 7, no. 2 (2014): 329-334. https://doi.org/10.3892/etm.2013.1409