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Article

Lithium chloride attenuates root resorption during orthodontic tooth movement in rats

  • Authors:
    • Yu Wang
    • Shang Gao
    • Huan Jiang
    • Peng Lin
    • Xingfu Bao
    • Zhimin Zhang
    • Min Hu
  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Endodontics, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 468-472
    |
    Published online on: November 15, 2013
       https://doi.org/10.3892/etm.2013.1410
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Abstract

Root resorption is a common side effect of orthodontic treatment. In the current study, lithium chloride (LiCl), a Wnt signaling activator, was examined to determine its effect on root resorption. In total, 10 Sprague Dawley rats were randomly allocated into the experimental group (EG) and control group (CG). Each group consisted of five subjects. By using closed nickel‑titanium coil springs, a 50‑g force was applied between the upper incisors and the maxillary right first molars in order to mimic orthodontic biomechanics in the EG and CG for 14 days. During the 14 days, the EG rats were gavage‑fed 200 mg/kg LiCl every 48 h. Next, digital radiographs were captured using a micro‑computational tomography scanner. The movement of the maxillary first molars and the root resorption area ratio were measured electronically on the digital radiographs. The outcomes were analyzed using ANOVA. Following 14 days of experimental force application, all rats had spaces of varying sizes between the first and second right maxillary molars. The average distance measured in the CG was slightly higher than in the EG, however, the difference was not found to be statistically significant (P=0.224). Root resorption craters were observed in the groups following the experiment. Rough cementum areas were observed on the mesial surface of the distobuccal and distopalatal roots. The mean root resorption area ratio of CG was significantly greater than EG (P<0.05). Results of the present study indicate that LiCl can attenuate orthodontically induce root resorption during orthodontic tooth movement. The effect of LiCl on tooth movement is insignificant.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Gao S, Jiang H, Lin P, Bao X, Zhang Z and Hu M: Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. Exp Ther Med 7: 468-472, 2014.
APA
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., & Hu, M. (2014). Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. Experimental and Therapeutic Medicine, 7, 468-472. https://doi.org/10.3892/etm.2013.1410
MLA
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., Hu, M."Lithium chloride attenuates root resorption during orthodontic tooth movement in rats". Experimental and Therapeutic Medicine 7.2 (2014): 468-472.
Chicago
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., Hu, M."Lithium chloride attenuates root resorption during orthodontic tooth movement in rats". Experimental and Therapeutic Medicine 7, no. 2 (2014): 468-472. https://doi.org/10.3892/etm.2013.1410
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Gao S, Jiang H, Lin P, Bao X, Zhang Z and Hu M: Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. Exp Ther Med 7: 468-472, 2014.
APA
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., & Hu, M. (2014). Lithium chloride attenuates root resorption during orthodontic tooth movement in rats. Experimental and Therapeutic Medicine, 7, 468-472. https://doi.org/10.3892/etm.2013.1410
MLA
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., Hu, M."Lithium chloride attenuates root resorption during orthodontic tooth movement in rats". Experimental and Therapeutic Medicine 7.2 (2014): 468-472.
Chicago
Wang, Y., Gao, S., Jiang, H., Lin, P., Bao, X., Zhang, Z., Hu, M."Lithium chloride attenuates root resorption during orthodontic tooth movement in rats". Experimental and Therapeutic Medicine 7, no. 2 (2014): 468-472. https://doi.org/10.3892/etm.2013.1410
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