mRNA expression of CK19, EGFR and LUNX in patients with lung cancer micrometastasis

Zhang,Xiansen; Xie,Jing; Yu,Changfa; Yan,Lixia; Yang,Zeshan

doi:10.3892/etm.2013.1417

2014-February Volume 7 Issue 2

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2014-February Volume 7 Issue 2

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Article

mRNA expression of CK19, EGFR and LUNX in patients with lung cancer micrometastasis

Authors:
- Xiansen Zhang
- Jing Xie
- Changfa Yu
- Lixia Yan
- Zeshan Yang
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, Taizhou First People's Hospital, Taizhou, Zhejiang 318020, P.R. China
Pages: 360-364
|
Published online on: November 19, 2013

https://doi.org/10.3892/etm.2013.1417
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Abstract

To evaluate the clinical significance of mRNA expression of cytokeratin 19 (CK19), epidermal growth factor receptor (EGFR) and lung‑specific X protein (LUNX), a total of 42 patients who were diagnosed with non‑small cell lung cancer (NSCLC) by pathology were studied retrospectively. The messenger RNA (mRNA) expression levels of CK19, EGFR and LUNX in the peripheral blood were analyzed using reverse transcription‑polymerase chain reaction (RT‑PCR). The expression of CK19 mRNA did not differ significantly according to the location, size, clinical stage or differentiation of the primary tumor (all P>0.05). However, there was a significant difference in the level of CK19 mRNA expression between squamous carcinoma and adenocarcinoma. The positive rates of EGFR mRNA in the patient and the healthy control groups were 69.0 and 12.5%, respectively, and were significantly different (P<0.05). The positive rates of LUNX mRNA in the two groups were 40.5 and 0%, respectively, and were significantly different (P<0.05). The results indicate that the mRNA expression of CK19, EGFR and LUNX in the peripheral blood is of significant clinical value for the diagnosis of micrometastasis and the prognosis of lung cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

mRNA expression of CK19, EGFR and LUNX in patients with lung cancer micrometastasis

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