LAPTM4B‑35 protein is a weak tumor‑associated antigen candidate

  • Authors:
    • Guilan Shi
    • Chunxia Zhou
    • Dongmei Wang
    • Wenbo Ma
    • Shuren Zhang
  • View Affiliations

  • Published online on: November 26, 2013     https://doi.org/10.3892/etm.2013.1427
  • Pages: 491-495
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Abstract

Lysosome‑associated protein transmembrane 4β (LAPTM4B) is a gene that has been indicated to be involved in cancer. It is located at chromosome 8q22 and is composed of seven exons and six introns. LAPTM4B encodes two protein isoforms: LAPTM4B‑35 and LAPTM4B‑24. LAPTM4B‑35 is markedly upregulated and LAPTM4B‑24 is downregulated in several types of cancer. LAPTM4B‑35 is 91 amino acids (N91) longer than LAPTM4B‑24 at the N‑terminus. In the present study, western blotting, enzyme‑linked immunosorbent spot analysis and the B16F10-N91 tumor bearing-mice experiments were used to evaluate whether the overexpression of N91 indicates its potential as a candidate tumor‑associated antigen. The results revealed that N91 was expressed in a wide range of normal mouse tissues and human peripheral blood mononuclear cells, with varying expression levels. The weak immunogenicity of N91 protein suggested it was a weak candidate antigen; however, the N91 protein was associated with cell proliferation.
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2014-February
Volume 7 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shi G, Zhou C, Wang D, Ma W and Zhang S: LAPTM4B‑35 protein is a weak tumor‑associated antigen candidate. Exp Ther Med 7: 491-495, 2014
APA
Shi, G., Zhou, C., Wang, D., Ma, W., & Zhang, S. (2014). LAPTM4B‑35 protein is a weak tumor‑associated antigen candidate. Experimental and Therapeutic Medicine, 7, 491-495. https://doi.org/10.3892/etm.2013.1427
MLA
Shi, G., Zhou, C., Wang, D., Ma, W., Zhang, S."LAPTM4B‑35 protein is a weak tumor‑associated antigen candidate". Experimental and Therapeutic Medicine 7.2 (2014): 491-495.
Chicago
Shi, G., Zhou, C., Wang, D., Ma, W., Zhang, S."LAPTM4B‑35 protein is a weak tumor‑associated antigen candidate". Experimental and Therapeutic Medicine 7, no. 2 (2014): 491-495. https://doi.org/10.3892/etm.2013.1427