Low‑dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study

Liu,Xiao‑Li; Wang,Xiao‑Zhi; Liu,Xiu‑Xiang; Hao,Dong; Jaladat,Yasaman; Lu,Feng; Sun,Ting; Lv,Chang‑Jun

doi:10.3892/etm.2013.1466

2014-March Volume 7 Issue 3

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2014-March Volume 7 Issue 3

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Article

Low‑dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study

Authors:
- Xiao‑Li Liu
- Xiao‑Zhi Wang
- Xiu‑Xiang Liu
- Dong Hao
- Yasaman Jaladat
- Feng Lu
- Ting Sun
- Chang‑Jun Lv
View Affiliations / Copyright

Affiliations: Department of Respiratory Disease, Hospital of Binzhou Medical University, Binzhou, Shandong 256603, P.R. China, Department of Otolaryngology‑HNS, Case Western Reserve University, Cleveland, OH 44106, USA
Pages: 604-608
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Published online on: December 31, 2013

https://doi.org/10.3892/etm.2013.1466
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Abstract

The present study aimed to investigate whether low‑dose heparin improves the condition of patients suffering from early disseminated intravascular coagulation (pre‑DIC) during sepsis. In total, 37 patients were randomly divided into low‑dose heparin intervention and control groups. The heparin group received a low‑dose of heparin for 5‑7 days, while the other group received only saline. The two groups were treated for sepsis. Blood samples were collected at various times and acute physiology and chronic health evaluation (APACHE)‑II scores were recorded at day 1 and 7. In addition, the number of days applying mechanical ventilation and in the intensive care unit (ICU) were recorded, as well as the 28‑day mortality rate. APACHE‑II scores in the two groups decreased following treatment, however, scores in the heparin group decreased more significantly. Prothrombin fragment and thrombin‑antithrombin complex levels in the heparin group were significantly decreased. In addition, the number of days applying a ventilator was fewer and the total stay in ICU was significantly shorter compared with the control group. Significantly fewer complications were observed in the heparin group, however, there was no significant difference in the 28‑day mortality rate. In conclusion, low‑dose heparin improves the hypercoagulable state of sepsis, which subsequently reduces the incidence of DIC or multiple organ dysfunction syndrome, decreasing the number of days of mechanical ventilation and hospitalization.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Low‑dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study

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