Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-March Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy

  • Authors:
    • Mian-Na Luo
    • Cui-Wei Yao
    • Bi-Hua Xu
    • Yong-Zhi Xu
    • Wei Jing Liu
    • Yong-Min Feng
    • Jing-Li Tao
    • Hua-Feng Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Nephrology, Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China
  • Pages: 553-559
    |
    Published online on: December 31, 2013
       https://doi.org/10.3892/etm.2013.1467
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to evaluate the effects of an individualized, low-dose multi-drug immunosuppressive regimen for the treatment of immunoglobulin A nephropathy (IgAN). A preliminary investigation of the course of IgAN following immunosuppressive treatment was conducted based on repeat renal biopsies. Clinical and pathological data of 17 patients with IgAN who received repeat renal biopsies were analyzed retrospectively. In addition to basic treatment, 16 patients regularly received an individualized low-dose immunosuppressive regimen according to their clinical manifestations and pathological patterns following the first biopsy. Clinical parameters, including 24-h urinary protein excretion and levels of serum albumin, uric acid and total cholesterol were collected. Glomerular deposits of IgA and C3, as well as the activity and chronicity indexes of renal lesions were evaluated by semi-quantitative methods. The 24‑h urinary protein excretion of the patients decreased significantly from the first biopsy (2.53±2.17 g/day) to the repeated biopsy (0.26±0.55 g/day) (P<0.001). Deposits of IgA and C3 in the glomerulus were persistent, but were reduced in quantity at the second biopsy. Although active renal lesions were observed in the majority of patients, the activity index decreased significantly from 3.18±1.33 prior to therapy to 2.47±0.80 following therapy (P<0.05), while the chronicity index did not change significantly (2.59±2.00 versus 2.76±1.89, respectively). The individualized, low-dose multi-drug immunosuppressive regimen used in the present study significantly minimized proteinuria, stabilized renal function and alleviated histological lesions in patients with IgAN without causing overt adverse effects during the short‑term follow-up. In addition to proteinuria, renal pathological changes should be appraised when considering the withdrawal of immunosuppressants from IgAN treatment.
View Figures

Figure 1

Figure 2

View References

1 

Floege J and Feehally J: IgA nephropathy: recent developments. J Am Soc Nephrol. 11:2395–2403. 2000.PubMed/NCBI

2 

Donadio JV and Grande JP: IgA nephropathy. N Engl J Med. 347:738–748. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Reich HN, Troyanov S, Scholey JW and Cattran DC; Toronto Glomerulonephritis Registry. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 18:3177–3183. 2007. View Article : Google Scholar : PubMed/NCBI

4 

D’Amico G: Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin Nephrol. 24:179–196. 2004.PubMed/NCBI

5 

Berthoux F, Mohey H, Laurent B, Mariat C, Afiani A and Thibaudin L: Predicting the risk for dialysis or death in IgA nephropathy. J Am Soc Nephrol. 22:752–761. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Coppo R, Cattran D, Roberts Ian SD, et al: The new Oxford Clinico-Pathological Classification of IgA nephropathy. Prilozi. 31:241–248. 2010.PubMed/NCBI

7 

Pozzi C, Bolasco PG, Fogazzi GB, et al: Corticosteroids in IgA nephropathy: a randomised controlled trial. Lancet. 353:883–887. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Harmankaya O, Oztürk Y, Baştürk T, Obek A and Kiliçarslan I: Efficacy of immunosuppressive therapy in IgA nephropathy presenting with isolated hematuria. Int Urol Nephrol. 33:167–171. 2002. View Article : Google Scholar : PubMed/NCBI

9 

KDIGO: Kidney Disease: Improving Global Outcomes. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int. 2(suppl): 209–217. 2012.

10 

Manno C, Torres DD, Rossini M, Pesce F and Schena FP: Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy. Nephrol Dial Transplant. 24:3694–3701. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Lv J, Zhang H, Chen Y, et al: Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial. Am J Kidney Dis. 53:26–32. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Andreoli SP and Bergstein JM: Treatment of severe IgA nephropathy in children. Pediatr Nephrol. 3:248–253. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Tamura S, Ueki K, Ideura H, et al: Corticosteroid therapy in patients with IgA nephropathy and impaired renal function. Clin Nephrol. 55:192–195. 2001.PubMed/NCBI

14 

Moriyama T, Honda K, Nitta K, Yumura W and Nihei H: The effectiveness of steroid therapy for patients with advanced IgA nephropathy and impaired renal function. Clin Exp Nephrol. 8:237–242. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Katafuchi R, Ikeda K, Mizumasa T, et al: Controlled, prospective trial of steroid treatment in IgA nephropathy: a limitation of low-dose prednisolone therapy. Am J Kidney Dis. 41:972–983. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Stangou M, Ekonomidou D, Giamalis P, et al: Steroids and azathioprine in the treatment of IgA nephropathy. Clin Exp Nephrol. 15:373–380. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Shima Y, Nakanishi K, Kamei K, et al: Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy. Nephrol Dial Transplant. 26:163–169. 2011.

18 

Qiu D and Kao PN: Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f Drugs R D. 4:1–18. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Lipsky PE and Tao XL: A potential new treatment for rheumatoid arthritis: thunder god vine. Semin Arthritis Rheum. 26:713–723. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Tao X and Lipsky PE: The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum Dis Clin North Am. 26:29–50. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Chen YZ, Gao Q, Zhao XZ, et al: Meta-analysis of Tripterygium wilfordii Hook F in the immunosuppressive treatment of IgA nephropathy. Intern Med. 49:2049–2055. 2010.PubMed/NCBI

22 

Bao H, Liu ZH, Xie HL, Hu WX, Zhang HT and Li LS: Successful treatment of class V+IV lupus nephritis with multitarget therapy. J Am Soc Nephrol. 19:2001–2010. 2008.

23 

Cheng J, Zhang X, Tian J, Li Q and Chen J: Combination therapy an ACE inhibitor and an angiotensin receptor blocker for IgA nephropathy: a meta-analysis. Int J Clin Pract. 66:917–923. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Cheng J, Zhang W, Zhang XH, He Q, Tao XJ and Chen JH: ACEI/ARB therapy for IgA nephropathy: a meta analysis of randomised controlled trials. Int J Clin Pract. 63:880–888. 2009. View Article : Google Scholar : PubMed/NCBI

25 

van Dixhoorn MG, Sato T, Muizert Y, van Gijlswijk-Janssen DJ, De Heer E and Daha MR: Combined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation. Kidney Int. 58:90–99. 2000.PubMed/NCBI

26 

Komatsu H, Fujimoto S, Hara S, Sato Y, Yamada K and Eto T: Relationship between serum IgA/C3 ratio and progression of IgA nephropathy. Intern Med. 43:1023–1028. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Lee SM, Rao VM, Franklin WA, et al: IgA nephropathy: morphologic predictors of progressive renal disease. Hum Pathol. 13:314–322. 1982. View Article : Google Scholar : PubMed/NCBI

28 

Glassock RJ: The treatment of IgA nephropathy: status at the end of the millenium. J Nephrol. 12:288–296. 1999.PubMed/NCBI

29 

Alexopoulos E: Treatment of primary IgA nephropathy. Kidney Int. 65:341–355. 2004. View Article : Google Scholar

30 

Usui J, Yamagata K, Kai H, et al: Heterogeneity of prognosis in adult IgA nephropathy, especially with mild proteinuria or mild histological features. Intern Med. 40:697–702. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo M, Yao C, Xu B, Xu Y, Liu WJ, Feng Y, Tao J and Liu H: Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy. Exp Ther Med 7: 553-559, 2014.
APA
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W.J., Feng, Y. ... Liu, H. (2014). Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy. Experimental and Therapeutic Medicine, 7, 553-559. https://doi.org/10.3892/etm.2013.1467
MLA
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W. J., Feng, Y., Tao, J., Liu, H."Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy". Experimental and Therapeutic Medicine 7.3 (2014): 553-559.
Chicago
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W. J., Feng, Y., Tao, J., Liu, H."Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy". Experimental and Therapeutic Medicine 7, no. 3 (2014): 553-559. https://doi.org/10.3892/etm.2013.1467
Copy and paste a formatted citation
x
Spandidos Publications style
Luo M, Yao C, Xu B, Xu Y, Liu WJ, Feng Y, Tao J and Liu H: Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy. Exp Ther Med 7: 553-559, 2014.
APA
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W.J., Feng, Y. ... Liu, H. (2014). Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy. Experimental and Therapeutic Medicine, 7, 553-559. https://doi.org/10.3892/etm.2013.1467
MLA
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W. J., Feng, Y., Tao, J., Liu, H."Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy". Experimental and Therapeutic Medicine 7.3 (2014): 553-559.
Chicago
Luo, M., Yao, C., Xu, B., Xu, Y., Liu, W. J., Feng, Y., Tao, J., Liu, H."Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy". Experimental and Therapeutic Medicine 7, no. 3 (2014): 553-559. https://doi.org/10.3892/etm.2013.1467
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team